摘要
额颞叶痴呆(FTD)是一组以进行性精神行为异常、执行功能障碍、语言功能损害为主要特征的痴呆疾病。少数FTD患者在疾病的某个时期也可出现运动异常。文中报道1例FTD伴帕金森综合征的患者的临床及多模态正电子发射体层摄影(PET)影像表现。18F-氟多巴PET示尾状核头为著的摄取减低,18F-AV-45 PET示淀粉样蛋白沉积阴性、18F-AV-1451 PET示新皮质tau沉积,综合支持潜在的额颞叶变性-tau病理。
Frontotemporal dementia(FTD)is a group of dementia diseases mainly characterized by progressive mental-behavioral abnormalities,executive dysfunction,and language impairment.A small number of FTD patients also present with movement disorders at certain disease course.Here the clinical and multimodal positron-emission tomography(PET)imaging manifestations in a patient with frontotemporal lobe dementia and parkinsonian syndrome are reported.18F-fluorodopa PET showed reduced uptake in the head of the caudate nucleus.18F-AV-45 PET showed negative amyloid deposition.18F-AV-1451 PET showed tau deposition in the neocortex.The clinical and neuroimaging features support the underlying frontotemporal lobar degeneration-tau pathology.
作者
邵靖雨
付畅
徐俊玲
陈帅
杨红旗
张杰文
Shao Jingyu;Fu Chang;Xu Junling;Chen Shuai;Yang Hongqi;Zhang Jiewen(Department of Neurology,People′s Hospital of Zhengzhou University,Henan Provincial People′s Hospital,Zhengzhou 450003,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2024年第11期1254-1258,共5页
Chinese Journal of Neurology
