摘要
额颞叶痴呆(frontotemporal dementia,FTD)是一组临床表型多样,遗传因素复杂,神经病理高度异质的以进行性人格行为改变,执行功能障碍及言语障碍为特征的神经退行性疾病。目前尚无有效治疗方法可以治愈或者逆转FTD进展,临床常采用对症治疗策略改善FTD患者神经精神、运动及认知症状。随着FTD发病机制的深入研究,越来越多靶向FTD突变基因及神经病理的药物正进入临床试验,以实现疾病的早期管理,精准治疗。本文主要就FTD治疗进展进行综述,有助于临床医师了解FTD最新治疗信息,提高FTD疾病管理。
Frontotemporal dementia(FTD)is a group of neurodegenerative diseases with diverse clinical phenotypes,complex genetic factors,and highly heterogeneous neuropathology,and it is characterized by progressive changes in personality and behavior,executive dysfunction,and speech and language impairment.Currently,there are no effective treatment methods that can cure FTD or reverse its progression,and in clinical practice,symptomatic treatment strategies are often used to improve the neuropsychiatric,motor,and cognitive symptoms of patients with FTD.With in-depth studies on the pathogenesis of FTD,clinical trials are being conducted for an increasing number of drugs that target the mutant genes and neuropathology of FTD,in order to achieve early management and precise treatment.This article reviews the advances in the treatment of FTD,so as to help clinicians understand the latest information for the treatment of FTD and improve disease management.
作者
岳爱玲
褚敏
武力勇
Yue Ailing;Chu Min;Wu Liyong(Department of Neurology,Xuanwu Hospital,Capital Medical University)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2024年第5期531-535,共5页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:82271464)。
关键词
额颞叶痴呆
治疗
基因靶向
Tau病理
神经调控
frontotemporal dementia
treatment
gene targeting therapy
Tau pathology
neuromodulation
