摘要
低浓度(ng/L至μg/L)的药物在环境水体中被广泛检出,其对水生生物存在潜在的生态风险,进而受到人们的关注.G蛋白偶联受体(GPCR)是一类在人体与动物体内高度保守的跨膜蛋白,约40%市售药物作用于GPCR.然而,GPCR药物在中国水环境中赋存情况及生态风险还未知.基于药物行业生产报告构建GPCR药物环境浓度预测模型,使用体外测试检测22种高产量GPCR药物的生物活性,最后基于预测浓度和体外生物活性建立地表水中GPCR药物的环境活性预测模型,筛选出中国地表水中需要优先控制的13种GPCR药物.
Pharmaceuticals with trace concentrations(ng/L-μg/L)have been widely detected in the aquatic environment.Concern about their potential ecological risks to aquatic species has been raised.G protein-coupled receptors(GPCR)are a class of membrane proteins that are highly conserved across species,and it is estimated that around 40%of marketed pharmaceuticals target GPCR.However,the occurrence and ecological risks of GPCR-acting pharmaceuticals in the aquatic environment in China remains unclear.Based on the pharmacy production report,an environmental concentration prediction model of GPCR-acting pharmaceuticals is developed.Then,the biological activities of 22 pharmaceuticals against corresponding GPCR with high production are investigated by an in vitro assay.Finally,a prediction model for environmental activities of GPCR-acting pharmaceuticals in surface water is established based on the predicted concentrations and in vitro biological activities,and 13 GPCR-acting pharmaceuticals are selected for priority control in surface water in China.
作者
郑有成
张晗
ZHENG Youcheng;ZHANG Han(Key Laboratory of Industrial Ecology and Environmental Engineering,Ministry of Education,School of Environmental Science and Technology,Dalian University of Technology,Dalian 116024,China)
出处
《大连理工大学学报》
CAS
CSCD
北大核心
2024年第6期573-580,共8页
Journal of Dalian University of Technology
基金
国家自然科学基金资助项目(22106018)
中央高校基本科研业务费专项资金资助项目(DUT20RC(3)080).
关键词
G蛋白偶联受体(GPCR)
G蛋白偶联受体药物
生物活性
生态风险
筛选
G protein-coupled receptors(GPCR)
G protein-coupled receptor-acting pharmaceuticals
biological activity
ecological risk
prioritization
