摘要
目的探讨D⁃二聚体(D⁃D)/血小板(PLT)比值(DPR)对慢性骨髓增殖性肿瘤(MPNs)患者血栓形成的预测价值。方法选取2020年12月至2023年12月于空军军医大学第二附属医院确诊的116例MPNs患者作为研究对象,根据是否有血栓形成分为血栓形成组34例和非血栓形成组82例。检测两组入院时D⁃D、PLT,并计算DPR,收集两组临床资料。采用受试者工作特性(ROC)曲线预测DPR对MPNs患者血栓形成的价值。采用二分类Logistic逐步回归分析探讨MPNs患者血栓形成的影响因素。结果血栓形成组DPR明显高于非血栓形成组,差异有统计学意义(P<0.05)。ROC结果显示,D⁃D、PLT以及DPR预测MPNs患者血栓形成的AUC(95%CI)分别为0.819(0.774~0.869)、0.754(0.709~0.799)、0.926(0.876~0.971)。血栓形成组年龄≥60岁、PV、血栓既往史、高血压史比例和血红蛋白、白细胞计数、纤维蛋白原水平高于非血栓形成组,差异有统计学意义(P<0.05)。多因素回归分析显示:年龄≥60岁(OR=2.522,95%CI:1.323~4.806)、有血栓既往史(OR=3.013,95%CI:1.468~6.186)、DPR≥1.40(OR=4.424,95%CI:2.092~9.353)是MPNs患者血栓形成的影响因素(P<0.05)。结论DPR高表达是MPNs患者的血栓形成的危险因素,可作为预测MPNs血栓形成的生物学标志物。
Objective To investigate the value of D⁃dimer(D⁃D)/platelet(PLT)ratio(DPR)in predicting thrombosis in patients with chronic myeloproliferative tumors(MPNs).Methods 116 patients with MPNs diagnosed at the Second Affiliated Hospital of Air Force Medical University from December 2020 to December 2023 were selected as the research subjects.They were divided into a thrombosis group of 34 cases and a non⁃thrombosis group of 82 cases based on the presence of thrombosis.D⁃D and PLT levels were detected at admission for both groups,and DPR was calculated.Clinical data for both groups were collected.The value of DPR in predicting thrombosis in MPNs patients was determined using ROC analysis.The influencing factors of thrombosis in MPNs patients were explored through binary logistic stepwise regression.Results The DPR in the thrombosis group was higher than that in the non⁃thrombosis group(P<0.05).The ROC results showed that the AUC(95%CI)for predicting thrombosis in MPNs patients using D⁃D,PLT,and DPR were 0.819(0.774~0.869),0.754(0.709~0.799),and 0.926(0.876~0.971),respectively.The thrombosis group had a higher proportion of patients aged≥60 years,PV,history of thrombosis,history of hypertension,as well as higher levels of hemoglobin,white blood cell count,and fibrinogen compared to the non⁃thrombosis group,and the differences were statistically significant(P<0.05).Age≥60 years old(OR=2.522,95%CI:1.323~4.806),history of thrombosis(OR=3.013,95%CI:1.468~6.186),DPR≥1.40(OR=4.424,95%CI:2.092~9.353)were identified as influencing factors of thrombosis in MPNs patients(P<0.05).Conclusion A high expression of DPR is a risk factor for thrombosis in MPNs patients and can serve as a biological marker for predicting thrombosis in MPNs.
作者
贺媛
任国平
张翠燕
田甜
胡静宇
HE Yuan;REN Guoping;ZHANG Cuiyan;TIAN Tian;HU Jingyu(Department of Hematological,the Second Affiliated Hospital of Air Force Military Medical University,Xi’an,Shaanxi,China,710038)
出处
《分子诊断与治疗杂志》
2024年第11期2186-2189,共4页
Journal of Molecular Diagnostics and Therapy
基金
陕西省重点研发计划项目(2023SF⁃197)。
