摘要
目的探讨多层螺旋CT(MSCT)扫描联合血清三叶因子3(TFF3)、可溶性B7-H4蛋白(sB7-H4)在食管癌患者术前分期评估中的临床价值。方法选取2022年8月~2023年9月本院确诊的116例食管癌患者为研究对象,患者均进行MSCT扫描检查,并依据术后病理结果进行分期。采用ELISA法检测血清TFF3、sB7-H4水平,绘制ROC曲线分析血清TFF3、sB7-H4水平对食管癌术前分期的评估价值。结果食管癌患者T分期中T1~T2、T3、T4血清TFF3、sB7-H4水平依次升高,N分期中N0、N1、N2血清TFF3、sB7-H4水平依次升高(P<0.05)。血清TFF3、sB7-H4水平评估T分期中T1~T2与T3的AUC分别为0.758、0.827,截断值分别为10.35 ng/mL、41.89μg/L;评估T分期中T3与T4的AUC分别为0.752、0.812,截断值分别为14.41 ng/mL、48.75μg/L。血清TFF3、sB7-H4水平评估N分期中N0与N1的AUC分别为0.827、0.853,截断值分别为10.94 ng/mL、42.38μg/L;评估N分期中N1与N2的AUC分别为0.825、0.805,截断值分别为15.03 ng/mL、50.19μg/L。MSCT扫描评估食管癌患者T分期的总诊断正确率为84.48%,N分期的总诊断正确率为83.62%。MSCT扫描联合血清TFF3、sB7-H4水平评估食管癌患者T分期的总诊断正确率为94.83%,高于MSCT扫描单独评估(P<0.05);N分期的总诊断正确率为93.97%,高于MSCT扫描单独评估(P<0.05)。结论MSCT扫描联合血清TFF3、sB7-H4水平,可有效提高评估食管癌患者分期的诊断正确率,应用价值较高。
Objective To explore the clinical value of multi-slice spiral CT(MSCT)scanning combined with serum trefoil factor 3(TFF3)and soluble B7-H4 protein(sB7-H4)in preoperative staging evaluation of esophageal cancer patients.Methods From August 2022 to September 2023,116 esophageal cancer patients diagnosed in our hospital were regarded as the study subjects.All patients underwent MSCT scanning and were staging based on postoperative pathological results.ELISA method was applied to detect serum TFF3 and sB7-H4 levels,and the ROC curve was plotted to analyze the evaluation value of serum TFF3 and sB7-H4 levels for preoperative staging of esophageal cancer.Results The levels of serum TFF3 and sB7-H4 in T1~T2,T3,and T4 stages of esophageal cancer patients increased sequentially,while the levels of serum TFF3 and sB7-H4 in N0,N1,and N2 stages increased sequentially(P<0.05).The AUC values of serum TFF3 and sB7-H4 levels in evaluating T1~T2 and T3 stage were 0.758 and 0.827,respectively,and the cutoff values were 10.35 ng/mL and 41.89μg/L,respectively;the AUCs of T3 and T4 in the evaluation of T-stage were 0.752 and 0.812,respectively,with cutoff values of 14.41 ng/mL and 48.75μg/L,respectively.The AUC values of N0 and N1 in evaluating N staging were 0.827 and 0.853,respectively,with cutoff values of 10.94 ng/mL and 42.38μg/L;the AUCs of N1 and N2 in the evaluation of N staging were 0.825 and 0.805,respectively,with cutoff values of 15.03 ng/mL and 50.19μg/L,respectively.The total diagnostic accuracy of MSCT scanning in evaluating the T-stage and N-stage of esophageal cancer patients was 84.48%and 83.62%,respectively.The overall diagnostic accuracy of MSCT scan combined with serum TFF3 and sB7-H4 levels in evaluating T staging of esophageal cancer patients was 94.83%,which was higher than that of MSCT scan alone(P<0.05);the overall diagnostic accuracy of N staging was 93.97%,which was higher than that of MSCT scan alone evaluation(P<0.05).Conclusion MSCT scanning combined with serum TFF3 and sB7-H4 levels can effectively
作者
宋世强
任义财
陈鑫
SONG Shi-qiang;REN Yi-cai;CHEN Xin(Department of Radiology,Sichuan Integrative Medicine Hospital,Chengdu 611100,Sichuan Province,China)
出处
《中国CT和MRI杂志》
2024年第11期75-77,共3页
Chinese Journal of CT and MRI
基金
四川省科技计划项目(2021YJ0249)。
