摘要
目的:探讨加味射干麻黄汤联合常规西医治疗哮喘急性发作期寒哮证患者的效果。方法:选择2021年10月—2023年9月漳浦县中医院收治的116例哮喘急性发作期寒哮证患者作为研究对象,采用随机数表法将患者分为对照组与观察组,各58例。对照组予以常规西医治疗,观察组在对照组基础上给予加味射干麻黄汤治疗,两组均连续治疗7 d。比较两组临床疗效、呼出气一氧化氮(FeNO)、肺功能、外周血嗜酸性粒细胞计数(EOS)、血清免疫球蛋白E(IgE)、中医症候积分及不良反应。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组FeNO、EOS、IgE、中医症候积分低于治疗前,第1秒用力呼气容积(FEV_(1))/用力肺活量(FVC)(FEV_(1)/FVC%)、FEV_(1)高于治疗前,观察组FeNO、EOS、IgE、中医症候积分低于对照组,FEV_(1)/FVC%、FEV_(1)高于对照组,差异有统计学意义(P<0.05)。两组均未见明显不良反应。结论:与单纯常规治疗相比,联合加味射干麻黄汤治疗哮喘急性发作期寒哮证患者效果更佳,更利于改善肺功能,缓解临床症状,降低FeNO、EOS、IgE水平,安全性好。
Objective:To explore the effect of Modified Shegan Mahuang Decoction combined with conventional western medicine in the treatment of patients with cold asthma syndrome in acute exacerbation of asthma.Method:A total of 116 patients with cold asthma syndrome in acute exacerbation of asthma who admitted to Zhangpu Hospital of Traditional Chinese Medicine from October 2021 to September 2023 were selected as the research objects,the patients were divided into the control group and the observation group by random number table method,with 58 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Modified Shegan Mahuang Decoction on the basis of the control group,two groups were treated for 7 d.The clinical efficacy,fractional exhaled nitric oxide(FeNO),pulmonary function,peripheral blood eosinophil count(EOS),serum immunoglobulin E(IgE),traditional Chinese medicine symptom score and adverse reactions were compared between two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of FeNO,EOS,IgE and traditional Chinese medicine symptoms in two groups were lower than those before treatment,and the forced expiratory volume in the first second(FEV_(1))/forced vital capacity(FVC)(FEV_(1)/FVC%)and FEV_(1) were higher than those before treatment,the FeNO,EOS,IgE and traditional Chinese medicine symptoms scores in the observation group were lower than those in the control group,and FEV_(1)/FVC%and FEV_(1) were higher than those in the control group,the differences were statistically significant(P<0.05).There were no obvious adverse reactions in two groups.Conclusion:Compared with conventional treatment alone,modified Shegan Mahuang decoction is more effective in the treatment of patients with cold asthma syndrome in acute exacerbation of asthma,which is more conducive to improving lung function,relieving clinical symptoms,
作者
邱岳明
陈智超
张晓玲
林晓君
QIU Yueming;CHEN Zhichao;ZHANG Xiaoling;LIN Xiaojun(Zhangpu Hospital of Traditional Chinese Medicine,Zhangpu 363200,China;不详)
出处
《中外医学研究》
2024年第31期34-38,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
哮喘
射干麻黄汤
呼出气一氧化氮
肺功能
Asthma
Shegan Mahuang Decoction
Fractional exhaled nitric oxide
Pulmonary function
