摘要
目的探索达格列净对2型糖尿病(T2DM)伴缺血性脑卒中(IS)患者血糖和认知功能的影响。方法收集2022年1月至2023年1月首都医科大学附属北京天坛医院神经内科收治的T2DM伴IS患者,随机分为达格列净组(常规治疗+达格列净降糖)和对照组(常规治疗+二甲双胍降糖),连续治疗6个月。在血糖管理方面,比较治疗前后的血糖控制水平和波动。采用蒙特利尔认知评估量表(MoCA)评估治疗前后的认知水平。结果研究共纳入100例患者,达格列净组和对照组各50例。治疗6个月后,两组患者的血糖水平和波动均较前下降(P<0.05),但达格列净组患者的血糖水平和波动更低(P<0.05);在认知功能方面,两组患者MoCA评分均较治疗前升高,而达格列净组患者的MoCA评分更高,尤其在视空间执行领域和延迟回忆上(P<0.05)。结论达格列净可以有效控制T2DM伴IS患者的血糖水平和血糖波动,并提高认知功能,尤其在视空间执行领域和延迟回忆上。
Objective To explore the effects of dapagliflozin on blood glucose and cognitive function in patients with type 2 diabetes mellitus(T2DM)and ischemic stroke(IS).Methods Patients with T2DM and IS admitted to the Department of Neurology,Beijing Tiantan Hospital,Capital Medical University from January 2022 to January 2023 were collected and randomly divided into dapagliflozin group(conventional treatment+dapagliflozin)and control group(conventional treatment+metformin)for 6 months of continuous treatment.Blood glucose control levels and fluctuations were compared before and after treatment.The Montreal Cognitive Assessment(MoCA)was used to evaluate cognitive function before and after treatment.Results A total of 100 patients were included in the study,50 in the dapagliflozin group and 50 in the control group.After 6 months of treatment,blood glucose levels and fluctuations decreased in both groups(P<0.05),but were lower in the dapagliflozin group(P<0.05).Regarding cognitive function,MoCA scores increased in both groups,with the dapagliflozin group showing higher scores,especially in visuospatial executive function and delayed recall(P<0.05).Conclusion Dapagliflozin can effectively control blood glucose levels and fluctuations in T2DM patients with IS,and improve cognitive function,particularly in visuospatial executive function and delayed recall.
作者
于美玲
张肖
李萍
YU Meiling;ZHANG Xiao;LI Ping(Three Wards of Vascular Neurology,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100071,China;Department of Brain Disease,Beijing Traditional Chinese Medicine Hospital Huairou Hospital,Beijing 101400,China;Three Department of Neurology,Hunan Provincial Brain Hospital,Changsha 410021,China)
出处
《药学前沿》
CAS
2024年第10期192-199,共8页
China Pharmacist
基金
北京中医医院怀柔医院科研项目(2020-MP04)。
关键词
达格列净
2型糖尿病
缺血性脑卒中
血糖
认知功能
Dapagliflozin
Type 2 diabetes
Ischemic stroke
Blood glucose
Cognitive function
