摘要
目的探究慢性肾小球肾炎(CGN)的临床治疗应用环孢素A免疫抑制剂的价值。方法选取2020年10月至2023年10月安阳市人民医院肾内科诊治的62例CGN病例,依据用药计划的差异,将其分为研究组(n=31,环孢素A+常规泼尼松治疗)、对照组(n=31,常规泼尼松治疗),分析其在临床疗效、肾功能指标,细胞血清因子方面的差异。结果治疗后,研究组治疗有效率(96.77%)显著高于对照组(70.97%),差异有统计学意义(P<0.05);治疗前两组肾功能指标差异无统计学意义(P>0.05);治疗后,研究组24 h尿蛋白定量(24 h UPR)、尿素氮(BUN)、血肌酐(SCr)水平均低于对照组,差异有统计学意义(P<0.05);治疗前两组血清细胞因子指标差异无统计学意义(P>0.05);治疗后,研究组可溶性血管内皮生长因子受体-1(sFIt-1)、溶酶体关联膜蛋白-2(LAMP-2)、Ⅰ型纤溶酶原激活物抑制剂(PAI-1)、白介素-17(IL-17)水平均低于对照组,差异有统计学意义(P<0.05)。结论应用环孢素A免疫抑制剂结合泼尼松治疗CGN,能够显著提升临床疗效,强化肾功能,降低患者血清细胞因子水平,值得临床应用。
Objective To explore the clinical value of using Cyclosporine A immunosuppressant in the treatment of chronic glomerulonephritis(CGN).Methods A total of 62 CGN cases treated at Anyang People's Hospital from October 2020 to October 2023 were selected.The patients were divided into a study group(n=31,treated with Cyclosporine A combined with conventional prednisone)and a control group(n=31,treated with conventional prednisone).The clinical efficacy,renal function indicators,and serum cytokine levels were analyzed and compared between the two groups.Results After treatment,the study group had a significantly higher treatment effective rate(96.77%)compared to the control group(70.97%),with statistical significance(P<0.05).There were no significant differences in renal function indicators between the two groups before treatment(P>0.05).After treatment,the 24-hour urine protein quantification(24h UPR),blood urea nitrogen(BUN),and serum creatinine(SCr)levels in the study group were significantly lower than those in the control group(P<0.05).Before treatment,there were no significant differences in serum cytokine levels between the two groups(P>0.05).After treatment,the levels of soluble vascular endothelial growth factor receptor-1(sFlt-1),lysosome-associated membrane protein-2(LAMP-2),plasminogen activator inhibitor-1(PAI-1),and interleukin-17(IL-17)in the study group were significantly lower than those in the control group(P<0.05).Conclusion The combination of Cyclosporine A and prednisone in the treatment of CGN can significantly improve clinical efficacy,enhance renal function,and reduce serum cytokine levels,making it worthy of clinical application.
作者
樊佳佳
FAN Jiajia(Department of Nephrology,Anyang People's Hospital,Anyang Henan 455000,China)
出处
《临床研究》
2024年第11期39-42,共4页
Clinical Research
关键词
环孢素A免疫抑制剂
慢性肾小球肾炎
疗效
肾功能
cyclosporine A immunosuppressive agents
chronic glomerulonephritis
clinical effects
renal function
