摘要
目的探讨多西环素与阿奇霉素序贯疗法在小儿肺炎支原体肺炎治疗中的临床应用效果。方法回顾性选取2023年1月—2024年4月绵阳市中心医院收治的100例小儿肺炎支原体肺炎患儿的临床资料。以不同治疗方法分为两组,每组50例。常规组采用阿奇霉素序贯疗法,探究组应用多西环素治疗。对比两组炎症指标水平、症状消失时间、呼吸功能。结果治疗后,探究组降钙素原、C反应蛋白、白细胞介素-6水平均低于常规组,第一秒用力呼气量、用力肺活量、第一秒用力呼气量占用力肺活量的百分比均高于常规组,差异有统计学意义(P均<0.05)。探究组高热寒战消失时间为(2.36±0.29)d、咳嗽咳痰消失时间为(8.33±2.28)d、呼吸困难消失时间为(4.63±1.45)d、胸闷气短消失时间为(5.39±1.33)d,短于常规组的(3.47±0.38)d、(12.17±2.10)d、(6.71±2.18)d、(7.47±2.42)d,差异有统计学意义(t=16.420、8.760、5.618、5.326,P均<0.05)。结论相比阿奇霉素序贯疗法,多西环素在小儿肺炎支原体肺炎的治疗中疗效更优,能降低炎症因子水平,改善呼吸功能,并缩短症状的持续时间。
Objective To explore the clinical application effect of doxycycline and azithromycin sequential therapy in the treatment of pediatric mycoplasma pneumoniae pneumonia.Methods The clinical data of 100 children with myco⁃plasma pneumoniae pneumonia admitted to Mianyang Central Hospital from January 2023 to April 2024 were retro⁃spectively selected.According to different treatment methods,they were divided into two groups,50 cases in each group.The conventional group was treated with azithromycin sequential therapy,and the exploration group was treated with doxycycline.The levels of inflammatory indicators,symptom disappearance time and respiratory function were compared between the two groups.Results After treatment,the levels of procalcitonin,C-reactive protein and interleu⁃kin-6 in the exploration group were lower than those in the conventional group,and the forced expiratory volume in the first second,forced vital capacity and forced expiratory volume in the first second/forced vital capacity were higher than those in the conventional group,and the differences were statistically significant(all P<0.05).The disap⁃pearance time of high fever and chills was(2.36±0.29)d,cough and expectoration was(8.33±2.28)d,dyspnea was(4.63±1.45)d,chest tightness and shortness of breath was(5.39±1.33)d in the exploration group,which were shorter than those in the conventional group(3.47±0.38)d,(12.17±2.10)d,(6.71±2.18)d,(7.47±2.42)d,and the differences were statistically significant(t=16.420,8.760,5.618,5.326,all P<0.05).Conclusion Compared with azithromycin se⁃quential therapy,doxycycline was more effective in the treatment of mycoplasma pneumoniae pneumonia in children.which can reduce the level of inflammatory factor levels,improve respiratory function,and shorten the duration of symptoms.
作者
杨霞
李艳
YANG Xia;LI Yan(Department of Pediatrics,Mianyang Central Hospital,Mianyang,Sichuan,621000,China)
出处
《中外医疗》
2024年第25期119-122,共4页
China & Foreign Medical Treatment
关键词
多西环素
阿奇霉素
序贯疗法
小儿肺炎支原体肺炎
Doxycycline
Azithromycin
Sequential therapy
Pediatric mycoplasma pneumoniae pneumonia
