摘要
目的探讨血清白细胞分化抗原14亚型(Presepsin)联合外周血常规检测对肝硬化合并自发性细菌性腹膜炎(SBP)的诊断价值。方法回顾性收集2023年2月~2024年2月首都医科大学附属北京地坛医院收治的108名肝硬化患者的临床资料。根据检测和诊断标准将其分为SBP组(n=46)和非SBP组(n=62),比较两组患者的一般资料、血清Presepsin水平和外周血常规指标[白细胞计数(WBC)、中性粒细胞计数(NE)、淋巴细胞计数(LYM)];采用受试者工作特征(ROC)曲线分析Presepsin联合外周血常规对肝硬化合并自发性细菌性腹膜炎的诊断效能。结果SBP组的Presepsin水平高于非SBP组,外周血常规指标WBC、NE、LYM也高于非SBP组,差异有统计学意义(t=7.188、5.947、4.978、4.816,P<0.05);血清Presepsin、WBC、NE、LYM与SBP均呈正相关(r=0.584、0.527、0.453、0.474,P<0.05);ROC结果显示,血清Presepsin、WBC、NE、LYM单独检测SBP的AUC面积分别是0.898、0.823、0.804、0.729,血清Presepsin联合外周血常规WBC、NE、LYM监测的AUC是0.978,高于各单独检测(P<0.005)。结论Presepsin在肝硬化合并SBP患者中的表达水平异常升高,Presepsin联合外周血常规检测对肝硬化合并SBP的诊断价值较高。
Objective To explore the diagnostic value of serum soluble CD14 subtype(Presepsin)combined with peripheral blood routine test on liver cirrhosis with spontaneous bacterial peritonitis(SBP).Methods The clinical data of 108 patients with liver cirrhosis admitted from February 2023 to February 2024 were retrospectively collected.According to the detection and diagnostic standards,they were divided into SBP group(n=46)and non-SBP group(n=62).The general data,serum Presepsin level,and peripheral blood routine indicators(WBC,NE,LYM)of the two groups of patients were compared.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficiency of Presepsin combined with peripheral blood routine test on liver cirrhosis with SBP.Results The level of Presepsin in the SBP group was higher than that in the non-SBP group,while the peripheral blood routine indicators of WBC,NE,and LYM were also higher than those in the non-SBP group(t=7.188,5.947,4.978,4.816,P<0.05).Serum Presepsin,WBC,NE,and LYM were positively correlated with SBP(r=0.584,0.527,0.453,0.474,P<0.05).The ROC results showed that the areas under the curve(AUCs)of serum Presepsin,WBC,NE,and LYM alone for detecting SBP were 0.898,0.823,0.804,and 0.729,respectively,and the AUC of serum Presepsin combined with peripheral blood WBC,NE,and LYM monitoring was 0.978,which was higher than each individual test(P<0.005).Conclusion The expression level of Presepsin is abnormally increased in patients with liver cirrhosis complicated with SBP.Presepsin combined with peripheral blood routine test has high diagnostic value on liver cirrhosis with SBP.
作者
王卉
刘晓
胡雨奇
刘京鹤
常宇飞
Wang Hui;Liu Xiao;Hu Yuqi(Department of Emergency,Beijing Ditan Hospital Affiliated to Capital Medical University,Beijing 100015,China)
出处
《中华保健医学杂志》
2024年第5期597-600,共4页
Chinese Journal of Health Care and Medicine
基金
首都医科大学附属北京地坛医院院内科研基金“启航计划”项目(DTQH202101)。
