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不同年龄的IBS患者胃肠激素、炎症水平特征及其与疾病严重程度的相关性分析

Characteristics of gastrointestinal hormones and inflammation levels in patients with IBS at different ages and their correlation with disease severity
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摘要 目的探讨不同年龄的肠易激综合征(IBS)患者胃泌素(GAS)、抑胃肽(GIP)等水平特征差异及其与疾病严重程度的相关性。方法选择2021年2月至2023年3月就诊于该院的IBS患者108例作为研究对象,根据IBS患者的临床分型划分为腹泻型IBS组(n=60)和便秘型IBS组(n=48)。根据各组患者入组时年龄是否大于60周岁分为老年组和非老年组。通过IBS症状严重程度量表(IBS-SSS)评估患者疾病严重程度;检测患者血清GAS、GIP、胃动素(MTL)、5-羟色胺(5-HT)等胃肠相关激素;检测白细胞介素(IL)-8、IL-10、IL-18及降钙素基因相关肽(CGRP)等炎症指标;通过Pearson相关性检验分析IBS-SSS与胃肠相关激素、炎症指标的相关性。通过多因素Logistic回归分析筛选患者发生重度IBS的独立危险因素。结果腹泻型IBS患者及便秘型IBS患者中,非老年组患者平均IBS-SSS评分显著高于老年组患者,且中度IBS患者比例高于老年组患者,差异有统计学意义(P<0.05);非老年组患者平均GAS、5-HT水平均显著高于老年组患者,差异有统计学意义(P<0.05),但GIP、MTL水平在两组间比较,差异无统计学意义(P>0.05);非老年组患者平均IL-18、CGRP水平均显著高于老年组患者,平均IL-10水平显著低于老年组患者,差异有统计学意义(P<0.05),但IL-8水平在两组间比较,差异无统计学意义(P>0.05);Pearson相关性分析表明在非老年IBS患者中、老年IBS患者及所有入组IBS患者中,IBS-SSS评分与血清5-HT、IL-18及CGRP均呈正相关(P<0.05);多因素Logistic回归分析表明,在非老年IBS患者中血清5-HT、IL-18及CGRP水平升高均是发生重度IBS的独立危险因素(P<0.05);在所有入组IBS患者中,仅血清5-HT水平升高是发生重度IBS的独立危险因素(P<0.05)。结论不论何种类型的IBS患者中,老年患者的病情严重程度轻于非老年患者,胃肠相关激素及炎症水平在不同年龄的患者间存在一定差异,其中血清5-HT、IL-18及CGRP水� Objective To investigate the differences in levels of serum gastrin(GAS)and gastric inhibitory peptide(GIP)in patients with irritable bowel syndrome(IBS)at different ages and their correlation with disease severity.Methods A total of 108 patients with IBS who were treated in the hospital from February 2021 to March 2023 were selected as the research objects.IBS patients were divided into diarrhea type IBS group(n=60)and constipation type IBS group(n=48)according to their clinical types,and were divided into elderly group and non elderly group according to whether the patients were older than 60 years at enrollment.The severity of disease was assessed by the IBS Symptom Severity Scale(IBS-SSS).Serum gastrointestinal related hormones such as GAS,GIP,motilin(MTL)and 5-hydroxytryptamine(5-HT)were detected.Inflammatory markers such as interleukin(IL)-8,IL-10,IL-18 and calcitonin gene-related peptide(CGRP)were detected.Pearson correlation test was used to analyze the correlation between IBS-SSS and gastrointestinal related hormones and inflammatory markers.Multivariate Logistic regression analysis was used to screen the independ-ent risk factors of severe IBS.Results Among diarrhea type IBS patients and constipation type IBS patients,the mean IBS-SSS score in the non elderly group was significantly higher than that in the elderly group,and the proportion of patients with moderate IBS was higher than that in the elderly group,and the differences were statistically significant(P<0.05).The mean levels of GAS and 5-HT in the non elderly group were sig-nificantly higher than those in the elderly group,and the differences were statistically significant(P<0.05),but there were no significant differences in the levels of GIP and MTL between the two groups(P>0.05).The mean levels of IL-18 and CGRP in the non elderly group were significantly higher than those in the elder-ly group,and the mean level of IL-10 in the non elderly group was significantly lower,and the differences were statistically significant(P<0.05),but there was n
作者 郭姗姗 雷强 芦萍 GUO Shanshan;LEI Qiang;LU Ping(Department of Internal Medicine,Xinjiang Uygur Autonomous Region First Jikun Hospital(Autonomous Region Fourth People's Hospital),Urumqi,Xinjiang 830017,China;Department of Information,Xinjiang Uygur Autonomous Region First Jikun Hospital(Autonomous Region Fourth People's Hospital),Urumqi,Xinjiang 830017,China)
出处 《国际检验医学杂志》 CAS 2024年第21期2632-2637,共6页 International Journal of Laboratory Medicine
基金 新疆维吾尔自治区自然科学基金资助项目(2020D01C416)。
关键词 肠易激综合征 胃肠相关激素 炎症指标 症状严重程度 irritable bowel syndrome gastrointestinal hormones inflammatory markers disease severity
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