摘要
目的:研究胃肠肽类激素酪酪肽(peptide yy,PYY)、胃动素(Motilin,MTL)、胃泌素(gastrin, GAS)在肠易激综合征(irritable bowel syndrome,IBS)病人血清的表达及其与炎性反应的关系。方法:采用收治的IBS患者100例为疾病组,另选我院同期体检正常者100例为对照组,观察两组血清PYY、MTL、GAS以及炎性因子表达水平、疾病组不同临床症状分型与血清PYY、MTL、GAS的相关性、疾病组患者血清PYY、MTL、GAS与炎症反应的相关性分析以及疾病组患者影响因素。结果:疾病组血清PYY、MTL、GAS以及炎性因子表达水平显著高于对照组,且腹泻型疾病组血清PYY、MTL、GAS以及炎性因子表达水平显著高于便秘型疾病组;腹泻型和便秘型患者血清PYY、MTL、GAS表达水平呈现负相关,腹泻型患者的与血清炎性因子呈现负相关,便秘型患者与炎性因子之间不存在相关性;腹泻型患者的血清PYY、MTL、GAS与炎症反应因子肿瘤坏死因子α(tumor necrosis factor,TNF-α)、白介素-6(Interleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)呈现正相关;患者的血清PYY、MTL、GAS表达水平均可作为IBS独立危险因素。结论:腹泻型IBS患者的血清PYY、MTL、GAS与患者的炎性因子表达水平呈现正相关,对于IBS疾病的诊断和治疗效果评价具有指导意义。
Objective: Expression of PYY, MTL and GAS in serum of IBS patients and their relationship with inflammatory response. Methods: Using 100 IBS patients admitted to our hospital from November 2016 toApril 2018as the observation group and 100 normal persons in the same period as the control group, we observed the levels of serum PYY, MTL, GAS and expression of inflammatory factors in the two groups, and the correlation between different clinical symptoms of the disease group and serum PYY, MTL, GAS. The correlation analysis between serum PYY, MTL, GAS and inflammatory response in patients with disease and the influencing factors of patients with disease. Results: The expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in control group, and the expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in patients with constipation. The expression levels of PYY, MTL and GAS in patients with diarrhea and constipation were negatively correlated. There was a negative correlation between serum inflammatory factors and DIARRHEA-TYPE patients, but no correlation between Constipation-Type patients and inflammatory factors. Serum PYY, MTL and GAS were positively correlated with inflammatory reaction factors TNF-a, IL-6 and IL-8 in DIARRHEA-TYPE patients. Serum PYY, MTL and GAS levels in patients with DIARRHEA-TYPE patients could be regarded as independent risk factors for IBS. Conclusion: The serum levels of PYY, MTL and GAS in patients with diarrhea IBS were positively correlated with the expression of inflammatory factors, which had guiding significance for the diagnosis and treatment of IBS.
作者
潘淑波
程秀琴
陈建生
史肖华
PAN Shu-bo;CHENG Xiu-qin;CHEN Jian-sheng;SHI Xiao-hua(Department of Gastroenterology, Suzhou Science and Technology City Hospital)
出处
《海南医学院学报》
CAS
2019年第4期276-279,共4页
Journal of Hainan Medical University
基金
苏州高新区医疗卫生科技计划项目(2016Q011)~~
