摘要
砷是一种重金属元素,属于一类致癌物。人类主要通过饮用水摄入砷,长期接触砷可造成癌性病变和非癌性病变,其中癌性病变包括胃癌。目前已知的无机砷暴露导致胃癌发生发展的机制主要包括氧化应激、表观遗传改变和免疫调节。氧化应激可引起肠上皮结构和功能的变化,导致肠道黏膜屏障受损进而癌变;表观遗传改变主要表现在DNA甲基化、组蛋白翻译后修饰以及影响miRNA的表达导致胃癌的发生发展;淋巴细胞、树突状细胞、巨噬细胞等免疫细胞的正常功能的损害可使胃肠道菌群失调,进一步发展为胃癌。
Arsenic is a heavy metal element and has been classified as group 1 carcinogens.Humans are mainly exposed to arsenic through drinking water.Long-term exposure to arsenic causes carcinomatous and non-carcinomatous lesions,including gastric carcinoma.At present,the known mechanisms of inorganic arsenic exposure leading to the occurrence and development of gastric cancer mainly include oxidative stress,epigenetic changes and immune regulation.Oxidative stress may change the structure and function of the intestinal epithelium,leading to damage to the intestinal mucosal barrier and then carcinoma.Epigenetic changes are mainly manifested in DNA methylation,histone post-translational modification and miRNA expression,which lead to the occurrence and development of gastric carcinoma.Impairment of the normal function of immune cells such as lymphocytes,dendritic cells,and macrophages may lead to dysbiosis of the gastrointestinal microbiota and development of gastric carcinoma.
作者
童玲
张靖雯
李帅
段开鹏
TONG Ling;ZHANG Jingwen;LI Shuai;DUAN Kaipeng(Department of Clinical Medicine,Soochow Medical College,Soochow University,Suzhou 215006;Department of Gastrointestinal Surgery,the First Affiliated Hospital of Soochow University,Suzhou 215006,China)
出处
《基础医学与临床》
CAS
2024年第11期1598-1602,共5页
Basic and Clinical Medicine
基金
国家自然科学基金青年科学基金(81700788)
苏州大学“大学生创新创业训练计划”基金资助(202210285070Z)。
关键词
砷
胃癌
氧化应激
表观遗传学
免疫调节
arsenic
gastric cancer
oxidative stress
epigenetics
immunoregulation
