摘要
癌症是世界上导致死亡的主要原因之一,其发病率不断上升.光疗以其无创、无耐受性、副作用小和操作方便等优势,已成为癌症精准治疗的新范式.自2001年唐本忠院士团队发现聚集诱导发光(AIE)现象以来,具有该性质的荧光材料被广泛用作高效光敏/光热试剂.因其高度扭曲的分子结构,避免了聚集态下的平面堆叠问题,从根本上解决了传统荧光材料聚集淬灭现象,显著提高了量子产率和光稳定性.作者详细对AIE材料作为光敏剂、光热剂及显影剂在癌症光疗(光动力治疗、光热治疗和光声成像)以及联合治疗中的最新应用进行了综述,并展望其未来发展趋势.
Cancer is a leading cause of death globally with its incidence rate on the rise.Phototherapy has emerged as a novel approach for precise cancer treatment,offering benefits such as non-invasiveness,no drug resistance,minimal side effects,and ease of operation.Since Prof.Ben Zhong Tang conceptually coined aggregation-induced emission(AIE)in 2001,AIE materials have been extensively applied as efficient photosensitive and photothermal agents.Thanks to their highly twisted molecular structure,AIE materials avoid the issue ofπ-πstacking in aggregated states,thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials.This advancement leads to a significant enhancement in quantum yield and photostability.Herein,the author comprehensively reviews the latest applications of AIE materials as photosensitizers,photothermal agents,and diagnostic agents in cancer phototherapy.
作者
孟子翔
田秀梅
张天富
Meng Zixiang;Tian Xiumei;Zhang Tianfu(School of Biomedical Engineering,Guangzhou Medical University,Guangzhou 511400)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2024年第8期2441-2452,共12页
Chinese Journal of Organic Chemistry
关键词
聚集诱导发光
光动力治疗
光热治疗
多模态联合治疗
aggregation-induced emission
photodynamics therapy
photothermal therapy
multimodal combination therapy
