摘要
代谢相关脂肪性肝病是一种与肥胖、2型糖尿病和高脂血症相关的慢性肝病,其发病率呈逐年上升趋势,严重影响患者的生活质量,给患者及社会带来沉重的医疗负担。其发病机制涉及多种因素,如二次打击与多重打击、幽门螺杆菌感染及交感神经的过度激活等,治疗方式有改变生活方式、改善胰岛素抵抗、调节肠道菌群、巨噬细胞靶向治疗等方面。该文就代谢相关脂肪性肝病的诊治进展作一综述。
Metabolic associated fatty liver disease is a chronic liver disease associated with obesity,type 2 diabetes and hyperlipidemia.The incidence of metabolic associated fatty liver disease is increasing year by year,which seriously affects the quality of life of patients and brings heavy medical burden to patients and society.Its pathogenesis involves a variety of factors,such as two-hit and multiple-hit,Helicobacter pylori infection and excessive activation of sympathetic nerves.The treatment methods include changing lifestyle,improving insulin resistance,regulating intestinal flora,and macrophage targeted therapy.This article reviews the progress in the diagnosis and treatment of metabolic associated fatty liver disease.
作者
刘钰(综述)
骆骁骐
谭晓燕(审校)
LIU Yu;LUO Xiaoqi;TAN Xiaoyan(The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China;Southern Medical University,Guangzhou,Guangdong 510515,China)
出处
《现代医药卫生》
2024年第20期3568-3572,共5页
Journal of Modern Medicine & Health
关键词
代谢相关脂肪性肝病
非酒精性脂肪性肝病
代谢综合征
胰岛素抵抗
幽门螺杆菌感染
综述
Metabolic associated fatty liver disease
Nonalcoholic fatty liver disease
metabolic syndrome
Insulin resistance
Helicobacter pylori infection
Review
