摘要
目的探讨子宫内膜异位症(EMT)患者血清B细胞淋巴瘤因子6(BCL6)和亲吻素水平与疾病进展的关系及诊断价值。方法选取2021年5月至2023年5月河南科技大学第一附属医院收治的110例EMT患者作为观察组,选取同期在本院进行体检的98名健康非EMT育龄期女性作为对照组。采用酶联免疫吸附试验法检测血清BCL6和亲吻素水平。比较观察组和对照组、不同痛经程度EMT患者、不同美国生育协会EMT分期标准(r-AFS)分期EMT患者血清BCL6和亲吻素水平,采用受试者工作特征(ROC)曲线分析血清BCL6和亲吻素水平对EMT的诊断价值,采用Logistic回归分析EMT患病的影响因素。结果观察组血清BCL6和亲吻素水平均高于对照组(P<0.05)。与轻度疼痛组比较,中、重度疼痛组血清BCL6和亲吻素水平升高(P<0.05);与中度疼痛组比较,重度疼痛组血清BCL6和亲吻素水平升高(P<0.05)。与Ⅰ~Ⅱ期组比较,Ⅲ、Ⅳ期组血清BCL6和亲吻素水平升高(P<0.05);与Ⅲ期组比较,Ⅳ期组血清BCL6和亲吻素水平升高(P<0.05)。血清BCL6和亲吻素联合诊断效能高于单独诊断。BCL6和亲吻素是EMT患病的独立危险因素(P<0.05)。结论EMT患者血清BCL6和亲吻素水平升高且与疾病进展有关,两者联合诊断价值较高。
Objective To investigate the relationship between serum B-cell lymphoma factor 6(BCL6),kisspeptin levels and disease progression in patients with endometriosis(EMT)and their diagnostic value.Methods A total of 110 EMT patients admitted to the First Affiliated Hospital of Henan University of Science and Technology from May 2021 to May 2023 were selected as the observation group,and 98 healthy non-EMT women of childbearing age who underwent physical examination in the same hospital during the same period were selected as the control group.Serum levels of BCL6 and kisspeptin were detected by enzyme-linked immunosorbent assay.Serum BCL6 and kisspeptin levels in the observation group and the control group,EMT patients with different dysmenorrhea degrees and EMT patients with different American Fertility Society EMT staging criteria(r-AFS)stages were compared,and the diagnostic value of serum BCL6 and kisspeptin levels in EMT patients was analyzed by receiver operating characteristic(ROC)curve.The influencing factors of EMT were analyzed by Logistic regression.Results The levels of serum BCL6 and kisspeptin in the observation group were both higher than those in the control group(P<0.05).Compared with the mild pain group,the levels of serum BCL6 and kisspeptin in the moderate and severe pain groups were increased(P<0.05).Compared with the moderate pain group,the levels of serum BCL6 and kisspeptin in the severe pain group were increased(P<0.05).Compared with stageⅠandⅡgroups,the levels of serum BCL6 and kisspeptin in stageⅢandⅣgroups were increased(P<0.05).Compared with stageⅢgroup,the levels of serum BCL6 and kisspeptin in stageⅣgroup were increased(P<0.05).The diagnostic efficacy of serum BCL6 and combined kisspeptin was higher than that of single diagnosis.BCL6 and kisspeptin were independent risk factors for EMT(P<0.05).Conclusions The levels of serum BCL6 and kisspeptin in EMT patients are increased and related to disease progression,and the combined diagnosis value of these two is high.
作者
温路瑶
王焱
任莉
WEN Luyao;WANG Yan;REN Li(Master Degree Candidate of Obstetrics and Gynecology Enrolled in 2021,the School of Clinical Medicine,Henan University of Science and Technology,Luoyang 471000,Henan,China;Department of Gynecology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China)
出处
《中国性科学》
2024年第10期65-69,共5页
Chinese Journal of Human Sexuality
基金
河南省医学科技攻关计划项目(LHGJ20220681)。
