摘要
中药谱效关系是利用数据分析技术将有效物质群特征峰与中药药效信息关联,反映中药物质成分与功效强度间复杂关系的一种方法。自中药谱效关系被提出后,由于其在中药活性成分群整体特征精细表达与中药多指标、多靶点作用机制联系上表现出的显著优势,现已被广泛应用于中药的质量控制、药效物质基础、炮制前后药效研究及有效部位筛选等研究领域。本文通过整理近十年中药谱效关系研究的相关文献资料,在中药谱效关系研究不断拓展、完善的新形势下,对中药谱效关系的研究策略及在中药多领域中的研究现状进行梳理与提炼,同时针对当前中药谱效关系研究存在的核心问题,进行初步分析展望,以期为谱效关系在中药多领域的深入研究提供参考。
The spectrum and efficacy of traditional Chinese medicine(TCM)is a method that uses data analysis to correlate the characteristic peaks of effective substance groups with the efficacy information of TCM,and reflects the complex relationship between the qualitative components of TCM and the efficacy intensity.Since the spectrum and efficacy concept of TCM was proposed,due to its significant advantages in the fine expression of the overall characteristics of the active ingredient group of TCM and the connection between the multi-index and multi-target mechanism of action of TCM,it has been widely used in the quality control,pharmacodynamic substance base,pre-and post-processing efficacy and effective site screening.By sorting out the relevant literature and materials of the research on the spectrum-efficacy relationship of TCM in recent years,this paper combined and refined the research strategies of the spectrum-efficacy relationship of TCM and the research status in various fields to continuously expand and improve the spectrum-efficacy of TCM.At the same time,the core problems were analyzed in the current research on the spectrum-efficacy relationship of TCM.This paper aiming to provide a reference for the in-depth study of spectrum-efficacy of TCM.
作者
周玲利
刘刚
刘育辰
穆开朗
ZHOU Ling-li;LIU Gang;LIU Yu-chen;MU Kai-lang(Guizhou University of Chinese Medicine,Guiyang 550025)
出处
《中南药学》
CAS
2024年第9期2398-2404,共7页
Central South Pharmacy
基金
国家自然科学基金项目(No.U1812403)
贵州省科技计划项目(黔科合基础-ZK[2022]一般475号)。
关键词
中药谱效关系
应用进展
指纹图谱
药效物质基础
质量控制
spectrum and efficacy of traditional Chinese medicine
application progress
fingerprint
material basis of efficacy
quality control
