摘要
目的 分析血清癌胚抗原(CEA)、胸苷激酶(TK1)、糖类抗原(CA)724、胃蛋白酶原I(PGI)/PGⅡ联合检测诊断早期胃癌的效果。方法 将2021年8月-2022年8月本院收治的89例早期胃癌患者纳入观察组;另将同期本院收治的90例胃良性病变患者纳入对照组;并将同期于本院行健康体检的85例健康人群纳入健康组,采集三组静脉血,检测对比其血清CEA、TK1、CA724、PGⅠ/PGⅡ的差异;另绘制受试者工作曲线(ROC),分析CEA、TK1、CA724、PGⅠ/PGⅡ联合检测诊断早期胃癌的效能。结果 观察组CEA为(19.84±2.23)ng/m L、TK1为(3.97±0.52)pmol/L、CA724为(42.89±5.31)U/m L,高于对照组的(2.57±0.26)ng/m L、(1.18±0.23)pmol/L、(4.15±0.57)U/m L与健康组的(2.36±0.35)ng/m L、(1.16±0.27)pmol/L、(3.87±0.46)U/m L,PGⅠ/PGⅡ为(2.31±0.26),低于对照组的(4.89±0.75)与健康组的(5.31±0.96),差异有统计学意义(P<0.05);ROC结果显示:CEA、TK1、CA724、PGⅠ/PGⅡ联合检测诊断早期胃癌的曲线下面积(AUC)为0.947(95%CI:0.910-0.984),高于几者单独检测的0.846(95%CI:0.787-0.904)、0.862(95%CI:0.801-0.922)、0.867(95%CI:0.814-0.919)、0.873(95%CI:0.819-0.928)。结论 早期胃癌患者机体内的CEA、TK1、CA724呈异常高表达,PGⅠ/PGⅡ呈异常低表达,四者联合可有效提高早期胃癌的诊断准确度,为临床提供可靠的依据,临床应用价值较高,值得大力推行。
Objective To analyze the effectiveness of combined detection of serum carcinoembryonic antigen(CEA),thymidine kinase(TK1),carbohydrate antigen(CA)724,and pepsinogen I(PGI)/PGII in the diagnosis of early gastric cancer.Methods 89 patients with early gastric cancer admitted to our hospital from August 2021 to August 2022 were included in the observation group;in addition,90 patients with benign gastric lesions admitted to our hospital during the same period were included in the control group;85 healthy people who underwent health examination in our hospital at the same time were included in the healthy group.Venous blood was collected from three groups,and the differences of serum CEA,TK1,CA724,PG I/PG II were detected and compared;additionally,draw a receiver operating curve(ROC)to analyze the efficacy of CEA,TK1,CA724,and PG I/PG II combined detection in the diagnosis of early gastric cancer.Results The CEA of the observation group was(19.84±2.23)ng/mL,TK1 was(3.97±0.52)pmol/L,and CA724 was(42.89±5.31)U/mL,which was higher than the control group's(2.57±0.26)ng/mL,(1.18±0.23)pmol/L,and(4.15±0.57)U/mL,and the healthy group's(2.36±0.35)ng/mL,(1.16±0.27)pmol/L,and(3.87±0.46)U/mL,with PG I/PG II being(2.31±0.26)and lower than the control group's(4.89±0.75).Compared to the healthy group(5.31±0.96),the difference was statistically significant(P<0.05);the ROC results showed that the area under the curve(AUC)for the combined detection of CEA,TK1,CA724,and PG I/PG II in the diagnosis of early gastric cancer was 0.947(95%CI:0.910-0.984),which was higher than the individual detection of 0.846(95%CI:0.787-0.904),0.862(95%CI:0.801-0.922),0.867(95%CI:0.814-0.919),and 0.873(95%CI:0.819-0.928).Conclusion The expression of CEA,TK1,and CA724 in early gastric cancer patients is abnormally high,while the expression of PGI/PGII is abnormally low.The combination of the four can effectively improve the diagnostic accuracy of early gastric cancer,provide reliable basis for clinical practice,and have high clinical application
作者
郑佳欣
ZHENG Jia-xin(Blood Transfusion Department,Jiaozuo People's Hospital,Jiaozuo 454001,Henan Province,China)
出处
《罕少疾病杂志》
2024年第9期88-90,共3页
Journal of Rare and Uncommon Diseases
关键词
早期胃癌
癌胚抗原
胸苷激酶
诊断效能
受试者工作曲线
曲线下面积
Early Gastric Cancer
Carcinoembryonic Antigen
Thymidine Kinase
Diagnostic Effectiveness
Subjects'Working Curve
Area under Curve
