摘要
目的 探讨拉莫三嗪联合左乙拉西坦治疗癫痫持续状态的临床疗效,为临床提高癫痫持续状态治疗效果提供经验。方法 选取并以随机数字表法将开封市中心医院2020年1月-2022年6月收治的74例癫痫持续状态患者分为观察组与对照组,各37例。对照组口服左乙拉西坦,观察组在对照组基础上联合应用拉莫三嗪,均治疗3个月。比较两组患者治疗效果,对比两组患者治疗前、治疗后认知功能及大脑异常放电数目变化情况,并对比两组不良反应发生情况。结果 经静脉注射地西泮10-20mg后,观察组有3例治疗无效,对照组有4例治疗无效,剔除后观察组剩余34例,对照组剩余33例;治疗3个月,观察组治疗总有效率大于对照组,差异有统计学意义(P<0.05);治疗3个月,两组蒙特利尔认知评定量表(Mo CA)评分均升高,且观察组高于对照组,差异具有统计学意义(P<0.05);两组患者大脑异常放电数目均减少,且观察组少于对照组,差异具有统计学意义(P<0.05);两组用药期间不良反应发生率对比,差异无统计学意义(P>0.05)。结论 应用拉莫三嗪联合左乙拉西坦治疗癫痫持续状态可显著提高临床疗效,改善患者认知功能,并减少大脑异常放电数目,且安全性良好。
Objective To explore the clinical efficacy of lamotrigine combined with levetiracetam in the treatment of status epilepticus,and to provide experience for improving the treatment effect of status epilepticus in clinical practice.Methods 74 patients with status epilepticus admitted to Department of Neurology of Kaifeng Central Hospital from January 2020 to June 2022 were selected and randomly divided into an observation group and a control group using a random number table method,with 37 patients in each group.The control group patients were treated with levetiracetam,while the observation group patients were treated with lamotrigine in combination on the basis of the control group.Both groups were treated for 3 months.The therapeutic effects of the two groups were compared.The changes of cognitive function and the number of abnormal brain discharges before and after treatment were compared,and the adverse reactions were compared between two groups.Results After intravenous injection of 10-20mg of diazepam,3 cases in the observation group showed ineffective treatment,while 4 cases in the control group showed ineffective treatment.After exclusion,there were 34 remaining cases in observation group and 33 remaining cases in control group.After 3 months of treatment,the total effective rate of observation group was higher than control group,with a statistical significant difference(P<0.05).After 3 months of treatment,the scores of the Montreal Cognitive Assessment Scale(MoCA)in both groups increased,and the observation group was higher than the control group,with a statistical significant difference(P<0.05).The number of abnormal brain discharges in both groups of patients decreased,and the observation group was less than the control group,with a statistical significant difference(P<0.05).There was no statistical significant difference in the incidence of adverse reactions between the two groups during the medication period(P>0.05).Conclusion The use of lamotrigine combined with levetiracetam in the treatment of statu
作者
魏淑娟
WEI Shu-juan(Department of Neurology,Kaifeng Central Hospital,Kaifeng 475000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第9期22-24,共3页
Journal of Rare and Uncommon Diseases
