摘要
目的:观察自拟补气活血汤联合四联疗法治疗幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)患者的临床效果及对胃肠功能、胃镜黏膜的影响。方法:将100例Hp感染致CAG患者按照随机数字表法分为对照组与观察组各50例。对照组运用四联疗法治疗,观察组在对照组基础上加用补气活血汤治疗。分析2组临床疗效、中医证候评分、胃肠道激素[血清胃泌素(GAS)、胃动素(MOT)]、胃镜黏膜征象评分、不良反应发生率以及Hp根除率、复发率。结果:观察组总有效率为96.00%,对照组为80.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组胃脘痞闷、胃痛、嗳气反酸、气短懒言、饮食减少、大便不畅等证候评分及总分均较治疗前下降(P<0.05),且观察组上述证候评分及总分均低于对照组(P<0.05)。治疗后,2组GAS、MOT含量均较治疗前升高(P<0.05),且观察组2项胃肠功能指标均高于对照组(P<0.05)。治疗后,2组黏膜颗粒状、黏膜血管暴露、黏膜皱襞变厚、黏膜色泽异常评分均较治疗前减少(P<0.05),且观察组上4项胃镜征象评分均低于对照组(P<0.05)。观察组不良反应发生率为10.00%,对照组为14.00%,2组比较,差异无统计学意义(P>0.05)。治疗后,观察组Hp根除率为98.00%,高于对照组84.00%,2组比较,差异无统计学意义(P>0.05)。随访3个月,观察组复发率为2.04%,低于对照组19.05%,2组比较,差异有统计学意义(P<0.05)。结论:补气活血汤联合四联疗法治疗Hp感染致CAG患者疗效良好,能够明显改善患者的临床症状,提高胃肠功能,修复胃黏膜,防止复发,并可在一定程度上提高Hp根除率。
Objective:To observe the clinical effect of self-made Buqi Huoxue Decoction combined with quadruple chemotherapy on helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG)and its effect on gastrointestinal function and gastroscopic mucosa.Methods:A total of 100 patients with CAG caused by Hp infection were randomly divided into the control group and the observation group,with 50 cases in each group,using a random number table method.The control group was treated with quadruple therapy,and the observation group was treated with Buqi Huoxue Decoction based on the control group.The clinical effects,traditional Chinese medicine syndrome scores,gastrointestinal hormones[serum gastrin(GAS)and motilin(MOT)],gastroscopic mucosal sign scores,incidence of adverse reactions,Hp eradication rate,and recurrence rate were analyzed in the two groups.Results:The total effective rate was 96.00%in the observation group,and 80.00%in the control group,the difference being significant(P<0.05).After treatment,the scores of epigastric distension,stomach pain,belching and acid reflux,shortness of breath and lazy speech,reduced diet and difficult bowel movements,as well as the total scores in both groups were decreased when compared with those before treatment(P<0.05),and the above syndrome scores and total score in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of GAS and MOT in the two groups were increased when compared with those before treatment(P<0.05),and the two gastrointestinal function indicators in the observation group were higher than those in the control group(P<0.05).After treatment,the scores of mucosal granulation,mucosal vascular exposure,thickening of mucosal folds,and abnormal mucosal color in both groups were decreased when compared with those before treatment(P<0.05),and the four gastroscopy signs in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 10.00%in the observation group,and 14.00%in the
作者
王金萍
华亚娜
蔡长春
朱宇斌
WANG Jinping;HUA Yana;CAI Changchun;ZHU Yubin(Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China;Internal Medicine Department of Shaoxing,Keqiao Women and Children's Hospital,Shaoxing Zhejiang 312000,China;Traditional Chinese Medicine Department of Shaoxing,Keqiao Women and Children's Hospital,Shaoxing Zhejiang 312000,China)
出处
《新中医》
CAS
2024年第18期72-76,共5页
New Chinese Medicine
关键词
慢性萎缩性胃炎
幽门螺杆菌
补气活血汤
四联疗法
胃镜黏膜征象评分
Chronic atrophic gastritis
Helicobacter pylori
Buqi Huoxue Decoction
Quadruple therapy
Gastroscopic mucosal sign scores
