摘要
目的基于美国药品不良事件报告系统(FAERS)数据库挖掘抗抑郁药(艾司氯胺酮、帕罗西汀和文拉法辛)自杀相关不良事件信号,为临床合理用药提供参考。方法利用报告比值比法(ROR)和相对报告比率(RRR)对FAERS数据库2004年1月—2023年9月接收的艾司氯胺酮、帕罗西汀和文拉法辛自杀不良事件信号进行挖掘与风险比较。结果基于FAERS数据库共检索到自杀相关不良事件报告10364份,其中艾司氯胺酮840份,帕罗西汀5802份,文拉法辛3722份。3种抗抑郁药均检测出自杀想法、自杀尝试和完成自杀3种不良事件信号,而帕罗西汀和文拉法辛还检测出自杀行为信号。结论3种抗抑郁药均存在相似的自杀风险信号,但不同抗抑郁药引起的自杀相关不良事件风险在不同年龄段存在差异。
Objective To mine the signals of suicide-related adverse events of antidepressants(esketamine,paroxetine and venlafaxine)based on FAERS database,to provide insights for clinically rational medication use.Methods The signals of suicide adverse events of esketamine,paroxetine and venlafaxine received in the FAERS database from January 2004 to September 2023 were mined and compared with reporting odds ratio(ROR)and relative reporting ratio(RRR)methods.Results A total of 10364 reports of suicide-related adverse events were retrieved based on the FAERS database,including 840 for esketamine,5802 for paroxetine,and 3722 for venlafaxine.All three antidepressants detected three adverse event signals:suicidal thoughts,suicide attempts,and completed suicide,while paroxetine and venlafaxine also detected suicidal behavior signals.Conclusion All three antidepressants have similar suicide risk signals,but the risk of suicide-related adverse events caused by different antidepressants varies across age groups.
作者
陈秋霞
苏斯
吴宋芬
庄海才
李宽
CHEN Qiuxia;SU Si;WU Songfen;ZHUANG Haicai;LI Kuan(Shantou University School Medicine College,Guangdong Province,Shantou 515041,China.;Department of Pharmacy,Shenzhen Mental Health Center/Shenzhen Kangning Hospital,Guangdong Province,Shenzhen 518020,China;不详)
出处
《临床合理用药杂志》
2024年第28期6-11,共6页
Chinese Journal of Clinical Rational Drug Use
基金
国家自然科学基金青年项目(81903581)
深圳市科技创新委员会基础研究面上项目(JCYJ20220530152216036)。
