摘要
目的:通过分析文献探析前庭周围性与中枢性眩晕用药规律异同。方法:通过检索中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库及中国生物医学文献数据库,纳入中药复方治疗前庭周围性眩晕及前庭中枢性眩晕的临床文献。构建方药数据库,通过数据挖掘技术(频次统计、关联规则、聚类分析)对高频药物及功效进行分析,运用Liquorice软件分析核心复方的配伍规律,获得组方用药规律及特点。结果:共纳入535篇文献,其中前庭周围性眩晕用药纳入文献243篇,前庭中枢性眩晕用药纳入文献292篇。频次分析结果显示,排在前五位的高频药物,前庭周围性眩晕用药为白术、半夏、茯苓、泽泻、甘草,前庭中枢性眩晕用药为川芎、天麻、半夏、葛根、白术;排在前五位的功效,前庭周围性眩晕用药为补气、化痰、利水渗湿、平肝息风、温阳;前庭中枢性眩晕用药为活血祛瘀、补气、平肝息风、化痰、利水渗湿。关联规则分析显示,支持度最高的前3位药对组合,前庭周围性眩晕:“白术-半夏”、“白术-茯苓”、“白术-泽泻”;前庭中枢性眩晕:“半夏-天麻”、“半夏-白术”、“葛根-川芎”。置信度最高的前3位药对组合,前庭周围性眩晕:“陈皮-半夏”、“竹茹-半夏”、“桂枝-茯苓”;前庭中枢性眩晕:“赤芍-川芎”、“桃仁-川芎”、“陈皮-半夏”。治疗前庭周围性眩晕、前庭中枢性眩晕的高频药物聚类分析分别获得4个、3个处方,运用复杂网络分析各获得1个核心处方。结论:眩晕为前庭周围性眩晕、前庭中枢性眩晕的共同临床表现,气虚、风、痰、瘀为共同的核心病机,痰、风更为关键,息风、化痰、益气、活血为主要治法。但前庭周围性眩晕侧重于水饮内盛,清阳不升,多配伍温阳化饮,升阳利水,和胃止呕的药物;前庭中枢性眩晕侧重于气虚血瘀,阴
Objective:To analyze the similarities and differences in medication rules of traditional Chinese medicine(TCM)in the treatment of vestibular peripheral vertigo(VPV)and vestibular central vertigo(VCV)based on the literature.Methods:CNKI,VIP,Wanfang Data,and SinoMed were searched for clinical studies of TCM prescriptions in the treatment of VPV and VCV to establish a database of prescriptions.The high-frequency drugs and their effects were analyzed by data mining techniques(frequency statistics,association rules,and cluster analysis).Liquorice software was used to analyze the combination rules of core prescriptions,and the medication rules and characteristics were obtained.Results:A total of 535 clinical studies were included,including 243 on VPV and 292 on VCV.Frequency analysis results showed that the top five drugs for the treatment of VPV were Baizhu(白术),Banxia(半夏),Fuling(茯苓),Zexie(泽泻),and Gancao(甘草),and the top five drugs for the treatment of VCV were Chuanxiong(川芎),Tianma(天麻),Banxia,Gegen(葛根),and Baizhu.The top five effects in the treatment of VPV were Buqi(补气),Huatan(化痰),Lishuishenshi(利水渗湿),Pingganxifeng(平肝息风),and Wenyang(温阳),and the top five effects in the treatment of VCV were Huoxuequyu(活血祛瘀),Buqi,Pingganxifeng,Huatan,and Lishuishenshi.Association rules analysis showed that the top three drug pairs with the highest support in the VPV group were Baizhu-Banxia,Baizhu-Fuling,and Baizhu-Zexie,and those in the VCV group were Banxia-Tianma,Banxia-Baizhu,and Gegen-Chuanxiong.The top three drug pairs with the highest degree of confidence in the VPV group were Chenpi(陈皮)-Banxia,Zhuru(竹茹)-Banxia,and Guizhi(桂枝)-Fuling,and those in the VCV group were Chishao(赤芍)-Chuanxiong,Taoren(桃仁)-Chuanxiong,and Chenpi-Banxia.The cluster analysis of high-frequency drugs showed four and three prescriptions in the VPV and VCV groups,respectively.The complex network analysis showed that one core prescription was obtained in each group.Conclusion:D
作者
韩德军
王丽
吕仕超
刘学政
HAN Dejun;WANG Li;LV Shichao;LIU Xuezheng(National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2024年第7期81-86,共6页
Pharmacology and Clinics of Chinese Materia Medica
基金
中华中医药学会青年人才托举工程项目(编号:CACM-2018-QNRC2-B04)
天津市卫生计生行业高层次人才选拔培养工程、天津中医药大学第一附属医院科研基金(编号:院2020052)。
关键词
梅尼埃病
良性阵发性位置性眩晕
前庭神经炎
后循环缺血
前庭性偏头痛
关联规则
聚类分析
Meniere's disease
Benign paroxysmal positional vertigo
Vestibular neuritis
Posterior circulation ischemia
Vestibular migraine
Association rules
Cluster analysis
