摘要
目的观察舒乳方治疗乳腺结节患者的临床疗效及对其性激素水平的影响。方法选取2022年10月—2023年12月期间在北京老年医院、北京市鼓楼中医医院因乳腺结节进行治疗的患者,北京老年医院纳入患者37例,北京市鼓楼中医医院纳入83例。按照随机数字表法分为对照组和治疗组,每组各60例。对照组给予雌激素受体拮抗剂他莫昔芬治疗,治疗组在对照组基础上应用舒乳方颗粒治疗。经过8周治疗后,评估两组患者临床疗效,治疗前后两组患者乳腺症状体征(乳腺疼痛分级、乳腺结节大小、乳腺质地评分和全身症状)量化评分、精神状况评分[焦虑自评量表(Self-rating anxiety scale,SAS)及抑郁自评量表(Self-rating depression scale,SDS)]、雌激素[血清催乳素(Prolactin,PRL)及雌二醇(Estradiol,E_(2))]水平。结果治疗后治疗组临床总有效率96.43%(54/56)高于对照组66.10%(39/59),差异有统计学意义(P<0.05)。治疗后两组患者乳腺疼痛、乳腺结节大小、乳腺结节质地、全身症状量化评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组乳腺症状体征量化评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者SAS、SDS评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组SAS、SDS评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者PRL和E2指标均较治疗前降低,差异有统计学意义(P<0.05);且治疗组PRL和E2指标均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论他莫昔芬联合舒乳方颗粒治疗乳腺结节患者具有良好的临床疗效,可有效降低患者激素水平。
Objective To observe the clinical efficacy of Shuru Fang granules in treating patients with breast nodules and its effect on their sex hormone levels.Methods Patients undergoing treatment for breast nodules between October 2022 and December 2023 were selected from Beijing Geriatric Hospital and Beijing Gulou Traditional Chinese Medicine Hospital.The study included 37 patients from Beijing Geriatric Hospital and 83 from Beijing Gulou Traditional Chinese Medicine Hospital.The patients were divided into a control group and a treatment group according to the random number table method,with 60 patients in each group.The control group received tamoxifen,an estrogen receptor antagonist,while the treatment group received Shu Rufang granules in addition to tamoxifen.After 8 weeks of treatment,clinical efficacy was evaluated in both groups.Quantitative scores were evaluated for breast symptoms and signs(breast pain grading,nodule size,breast texture score,and systemic symptoms),mental status scores[Self-rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)],and estrogen levels[serum prolactin(PRL)and estradiol(E_(2))]before and after treatment.Results After treatment,the overall clinical effective rate in the treatment group was 96.43%(54/56),significantly higher than 66.10%(39/59)in the control group,with a statistically significant difference(P<0.05).The quantitative scores for breast pain,nodule size,nodule texture,and systemic symptoms in both groups significantly decreased after treatment compared to before treatment,with statistically significant differences(P<0.05).Additionally,the quantitative scores in the treatment group were significantly lower than those in the control group,with statistically significant differences(P<0.05).Both SAS and SDS scores significantly decreased in both groups after treatment,with statistically significant differences(P<0.05);SAS and SDS scores in the treatment group were significantly lower than those in the control group,with statistically significant differences(P<0.05).PR
作者
李同达
丁亚丛
韩丹阳
付雪松
曹洪福
LI Tong-da;DING Ya-cong;HAN Dan-yang;FU Xue-song;CAO Hong-fu(Department of Traditional Chinese Medicine,Beijing Geriatric Hospital,Beijing 100095;Beijing Gulou Traditional Chinese Medicine Hospital,Beijing 100009;Peking University Cancer Hospital,Beijing 100142)
出处
《世界中西医结合杂志》
2024年第8期1577-1581,共5页
World Journal of Integrated Traditional and Western Medicine
基金
首都卫生发展科研专项(首发2022-3-7017)。
关键词
乳腺结节
舒乳方
雌激素
Breast Nodules
Shuru Fang
Estrogen
