摘要
目的:分析磁共振脂肪定量(MRFQ)技术在非酒精性脂肪性肝病(NAfld)患者小柴胡汤加减联合水飞蓟素胶囊治疗疗效评估中的应用价值。方法:选取2019年10月至2022年9月上海中医药大学附属曙光医院收治的130例NAfld患者,按1∶1比例原则分为例数相等的对照组和观察组,每组65例。对照组采用水飞蓟素胶囊治疗,观察组采用小柴胡汤加减联合水飞蓟素胶囊治疗,两组患者均在治疗前后采用MRFQ技术检查,比较治疗前后肝脏脂肪分量(F)、质子密度脂肪分数(PDFF)值,分析F、PDFF与脂肪肝的相关性。结果:观察组治疗总有效率为96.92%(63/65),对照组为83.08%(54/65),差异有统计学意义(x^(2)=6.923,P<0.05);两组患者治疗后经MRFQ技术检查,观察组65例患者脂肪肝检测正常35例(占53.85%),轻度脂肪肝22例(占33.85%),中度脂肪肝8例(占12.31%);对照组65例患者脂肪肝检测正常24例(占36.92%),轻度脂肪肝24例(占36.92%),中度脂肪肝14例(占21.54%),重度脂肪肝3例(占4.62%);两组脂肪肝检测正常率比较,差异有统计学意义(Z=8.755,P<0.05)。治疗后观察组脂肪(BF)、体脂率(BFR)、内脏脂肪面积(VFA)、体质量指数(BMI)及腰臀比(WHR)均低于对照组,差异有统计学意义(t=6.092、3.991、4.733、5.437、2.413,P<0.05)。治疗后观察组F值、PDFF值均低于对照组,差异有统计学意义(t=9.577、6.589,P<0.05)。随着脂肪肝等级增加,治疗后患者的肝脏F值、PDFF值越高。采用Spearson进行相关性分析,肝脏F值、PDFF值与肝脏脂肪等级为正相关性(r=0.618、0.648,P<0.05)。结论:MRFQ技术可发现NAfld患者经小柴胡汤加减联合水飞蓟素胶囊后,肝脏脂肪含量明显降低,根据MRFQ技术可相应评价患者治疗后的病情程度,为临床治疗效果评价提供客观性依据。
Objective:To analyze application value of magnetic resonance fat quantification(MRFQ)technique in assessing the therapeutic effect of modified Xiaochaihu decoction combined with silymarin capsules for patients with non-alcoholic fatty liver disease(NAfld).Methods:A total of 130 cases of NAfld patients admitted to Shuguang Hospital of Shanghai University of Traditional Chinese Medicine from October 2019 to September 2022 were selected,and they were randomly divided into a control group and an observation group,with 65 cases in each group according to the principle of 1:1 ratio.The control group was treated with silymarin capsules,and the observation group was treated with modified Xiao Chaihu decoction combined with silymarin capsules.Both two groups of patients were examined by FQD technique before and after treatment,and liver fat fraction(F)and proton-density fat fraction(PDFF)before and after treatment were compared between the two groups.The correlation between F value,FDFF value and fatty liver was further analyzed.Result:The total effective rate of the observation group was 96.92%(63/65),while that of the control group was 83.08%(54/65),with a statistically significant difference(x^(2)=6.923,P<0.05).After treatment,the results of FQD technique examination indicated that 35 cases(53.85%)were normal,and 22 cases(33.85%)were mild fatty liver,and 8 cases(12.31%)were moderate fatty liver in 65 cases of observation group,and 24 cases(36.92%)were normal,and 24 cases(36.92%)were mild fatty liver,and 14 cases(21.54%)were moderate fatty liver,and 3 cases(4.62%)were severe fatty liver in 65 cases of control group.The difference of normal rate between the two groups was statistically significant(Z=8.755,P<0.05).After treatment,the body fat(BF),body fat rate(BFR),visceral fat area(VFA),body mass index(BMI)and waist hip ratio(WHR)in the observation group were lower than those in the control group,and the differences were statistically significant(t=6.092,3.991,4.733,5.437,2.413,P<0.05),respectively.After treatment,the F
作者
王依希
季盛
耿坚
卓蕴慧
Wang Yixi;Ji Sheng;Geng Jian;Zhuo Yunhui(Department of Hepatology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China;Department of Traditional Chinese Medicine,Lingyun Community Health Service Center,Xuhui District of Shanghai,Shanghai 200030,China;Department of Radiology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China)
出处
《中国医学装备》
2024年第9期65-70,共6页
China Medical Equipment
基金
上海市科技计划项目(19401934100)
上海市徐汇区医学科研项目(SHXH202129)。
