摘要
目的分析锦州地区体检人群血清25-(OH)-D水平与非酒精性脂肪肝(nonalcohol fatty liver disease,NAFLD)的相关性。方法选取1975例在锦州医科大学附属第一医院健康管理中心体检者,收集整理体检者的数据资料进行横断面研究。根据超声结果将受试者分为NAFLD组和对照组,比较两组维生素D水平及临床代谢指标的差异;应用Spearman相关分析25-(OH)-D与NAFLD的相关性;根据维生素D缺乏标准分为缺乏组(<20 ng/mL)、不足组(20~30 ng/mL)和适宜组(≥30 ng/mL),并且采用二元logistic回归分析评估组间NAFLD的患病风险。结果除外25-(OH)-D和高密度脂蛋白胆固醇这2个指标,NAFLD组中其余指标均高于对照组,差异有统计学意义(P<0.05);NAFLD组25-(OH)-D缺乏率明显高于对照组(P<0.05);血清25-(OH)-D与NAFLD存在负相关(r=-0.148,P<0.001);以缺乏组为参考,未校正混杂因素前,不足组与缺乏组的患病风险不相关,正常水平组与缺乏组的患病风险存在负相关(P<0.05);在调整众多混杂因素后,不足组和正常水平组的患病风险是缺乏组的0.595倍和0.580倍(P<0.05),呈显著负相关。结论锦州地区维生素D缺乏和NAFLD患病率均较高,需要引起重视,应当合理调整优化饮食生活习惯;25-(OH)-D缺乏可能会增加NAFLD患病风险。
Objective To analyze the correlation between 25-hydroxyvitamin D level and nonalcohol fatty liver disease(NAFLD)in population in Jinzhou.Methods A total of 1,975 healthy subjects were recruited from the Physical Research Center of the First Affiliated Hospital of Jinzhou Medical University,subject data was collected and sorted for a cross-sectional study.Based on the ultrasound results,participants were divided into a non-alcoholic fatty liver group(NAFLD)and a control group.Differences in vitamin D levels and clinical metabolic indices were compared between two groups.Spearman correlation was used to analyze the 25-(OH)-D correlation with NAFLD.According to the vitamin D deficiency criteria,it was divided into deficiency group(<20 ng/mL),insufficient group(20-30 ng/mL)and appropriate group(≥30 ng/mL).The risk of inter-group NAFLD was evaluated by binary logistic regression analysis.Results Except for the two indices 25-(OH)-D and HDL-C,the other indices in the NAFLD group were higher and the difference was statistically significant compared to the control group(P<0.05).The 25-(OH)-D deficiency rate in NAFLD group was significantly higher than that in control group(P<0.05).Serum 25-(OH)-D was negatively correlated with NAFLD(r=-0.148,P<0.001).Taking the deficiency group as reference,before adjusting for confounding factors,the insufficient group was not associated with the the deficient group,the normal level group was negatively correlated with the defective group(P<0.05).After adjusting for many confounding factors,the risk in insufficient group and optimal level group was 0.595 times and 0.580 times higher,compared with deficiency group,which showed a distinct negative correlation.Conclusions Due to the high incidence of vitamin D deficiency and NAFLD in Jinzhou area,it should be paid attention to.Diet and lifestyle should be adjusted and optimized reasonably.25-(OH)-D deficiency may increase the risk of NAFLD.
作者
张新宇
徐锦江
ZHANG Xin-yu;XU Jin-jiang(School of Nursing,Jinzhou Medical University,Jinzhou,Liaoning 121000,China;不详)
出处
《慢性病学杂志》
2023年第10期1445-1448,1453,共5页
Chronic Pathematology Journal
关键词
非酒精性脂肪肝
维生素D
体检
Nonalcohol fatty liver disease
Vitamin D
Physical examination
