摘要
从DNA损伤和错误修复角度阐述了环境中抗生素抗性基因(Antibiotics resistance genes,ARGs)的形成机制,并对DNA损伤和错误修复过程中涉及的相关核心功能基因片段进行归纳总结。也从细胞代谢角度阐述了环境中ARGs进行水平传播的三种主要机制,包括:菌毛架桥作用、信号传导和IV型细胞分泌系统。现有研究进一步加强对ARGs在环境中形成和传播机制的认识,为今后研究ARGs的削减提供理论依据。目前关于抗生素诱导ARGs形成和传播的内在机制仍相对缺乏,后续可从生物毒性和分子生物学层面进行深入研究。
The formation mechanism of antibiotics resistance genes(ARGs)in the environment was described from the perspective of DNA damage and error repair,and the relevant core functional gene fragments involved in DNA damage and error repair were summarized.Three main mechanisms of horizontal transfer of ARGs in the environment,including pili bridging,signal transduction and type IV cell secretion system were discussed from the perspective of cell metabolism.The existing studies further strengthen the understanding of the formation and transfer mechanism of ARGs in the environment,and provide a theoretical basis for future research on the reduction of ARGs.At present,the internal mechanism of antibiotic induced ARGs formation and transfer was still relatively lacking,and further studies could be conducted from the biological toxicity and molecular biology levels.
作者
唐涛涛
赵晓龙
王胤
杨舒茗
吴嘉利
朱榕鑫
TANG Taotao;ZHAO Xiaolong;WANG Yin;YANG Shuming;WU Jiali;ZHU Rongxin(Southwest Municipal Engineering Design&Research Institute of China Co.,Ltd.,Chengdu 610084,China)
出处
《应用化工》
CAS
CSCD
北大核心
2024年第8期1980-1984,1988,共6页
Applied Chemical Industry
基金
四川省科技厅计划项目(2021ZHZY0002)
四川省住建厅计划项目(SCJSKJ2022-26)。
