摘要
目的分析血清可溶性血管内皮生长因子受体-1(sFlt-1)、热休克蛋白70(HSP70)与妊娠期高血压疾病严重程度的相关性。方法选取2021年12月至2022年12月在河北中石油中心医院就诊的35例单纯妊娠期高血压患者作为妊娠期高血压组,根据患者病情严重程度分为轻度、中度和重度妊娠期高血压,35例子痫前期患者作为子痫前期组,另选取同期在河北中石油中心医院体检的35例正常妊娠期孕妇作为对照组。比较3组血清sFlt-1、HSP70、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平。采用Pearson相关分析妊娠期高血压患者血清sFlt-1水平和HSP70水平的相关性,Spearman相关分析血清sFlt-1、HSP70水平与妊娠期高血压疾病严重程度的相关性。采用多因素Logistic回归分析妊娠期高血压发生的危险因素。绘制受试者工作特征(ROC)曲线分析血清sFlt-1和HSP70对子痫前期的诊断价值。结果妊娠期高血压组和子痫前期组血清sFlt-1、HSP70水平高于对照组,且子痫前期组高于妊娠期高血压组,差异均有统计学意义(P<0.05)。轻、中、重度妊娠期高血压患者分别有16、12、7例。中、重度妊娠期高血压患者血清sFlt-1、HSP70水平显著高于轻度妊娠期高血压患者,且重度妊娠期高血压患者血清HSP70水平高于中度妊娠期高血压患者,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,妊娠期高血压患者血清sFlt-1水平与HSP70水平呈正相关(r=0.586,P<0.05)。Spearman相关分析结果显示,血清sFlt-1、HSP70水平与妊娠期高血压疾病严重程度呈正相关(r s=0.512、0.627,P<0.05)。多因素Logistic回归分析结果显示,血清sFlt-1、HSP70水平升高是妊娠期高血压发生的危险因素(P<0.05)。ROC曲线分析结果显示,血清sFlt-1、HSP70单独诊断子痫前期的曲线下面积(AUC)分别为0.861、0.871,2项指标联合诊断子痫前期的AUC为0.951,均高于sFlt-1、H
Objective To analyze the correlation between serum soluble vascular endothelial growth factor receptor-1(sFlt-1),heat shock protein 70(HSP70)and the severity of gestational hypertension.Methods A total of 35 patients with simple gestational hypertension who were treated in Hebei Petrochina Central Hospital from December 2021 to December 2022 were selected as the gestational hypertension group,which were divided into mild,moderate and severe gestational hypertension according to the severity of the disease,35 examples of preeclampsia patients as a preeclampsia group.Another 35 normal pregnant women who underwent physical examination in Hebei Petrochina Central Hospital during the same period were selected as the control group.Serum levels of sFlt-1,HSP70,total cholesterol,triglyceride,low density lipoprotein cholesterol and high density lipoprotein cholesterol were compared among the three groups.Pearson correlation was used to analyze the correlation between serum sFlt-1 level and HSP70 level in patients with gestational hypertension,and Spearman correlation was used to analyze the correlation between serum sFlt-1,HSP70 levels and the severity of hypertensive diseases during pregnancy.Multivariate Logistic regression was used to analyze the risk factors of gestational hypertension.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum sFlt-1 and HSP70 in preeclampsia.Results The levels of serum sFlt-1 and HSP70 in gestational hypertension group and preeclampsia group were higher than those in control group,and those in preeclampsia group were higher than those in gestational hypertension group,and the differences were statistically significant(P<0.05).There were 16,12 and 7 cases of mild,moderate and severe gestational hypertension respectively.The serum levels of sFlt-1 and HSP70 in patients with moderate and severe gestational hypertension were significantly higher than those in patients with mild gestational hypertension,and the serum levels of HSP70 in patients with sev
作者
王建美
吴亚男
安泓润
WANG Jianmei;WU Ya′nan;AN Hongrun(Department of Obstetrics and Gynecology,Hebei Petrochina Central Hospital,Langfang,Hebei 065000,China)
出处
《检验医学与临床》
CAS
2024年第18期2751-2754,2770,共5页
Laboratory Medicine and Clinic
基金
河北省廊坊市科技支撑计划项目(2022013125)。
