摘要
目的:观察芪桂温补汤加减治疗对重度子痫前期(ESPE)患者血清可溶性血管内皮生长因子受体-1(sFlt1)、同型半胱氨酸(Hcy)、胎盘生长因子(PLGF)水平的影响。方法:选取2020年1月~2022年6月94例ESPE患者,随机分成研究组(n=47)与对照组(n=47),对照组给予常规药物治疗,研究组予以常规药物联合芪桂温补汤加减治疗。评价两组疗效,中医证候积分、血压、尿蛋白、血清sFlt1、Hcy、PLGF水平及氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平及妊娠结局。结果:研究组治疗总有效率为93.62%,高于对照组的74.47%(P<0.05),且研究组各中医证候积分低于对照组(P<0.05)。此外,治疗后研究组SBP、DBP、尿蛋白、血清sFlt1、Hcy、MDA水平较对照组低(P<0.05);血清PLGF及SOD水平较对照组高(P<0.05)。研究组患者剖宫产率及产后出血率分别为21.28%、17.02%,显著低于对照组的40.43%、36.17%(P<0.05)。结论:芪桂温补汤加减治疗ESPE疗效确切,能有效改善患者血压、尿蛋白及血清sFlt1、Hcy及PLGF水平,同时有助于减轻氧化应激反应,改善妊娠结局。
Objective:To observe the effect of modified Qigui Wenbu Decoction on serum soluble vascular endothelial growth factor receptor-1(sFlt1),homocysteine(Hcy)and placental growth factor(PLGF)levels in patients with severe preeclampsia(ESPE).Methods:A total of 94 patients with ESPE from January 2020 to June 2022 were selected and randomly divided into a study group(n=47)and a control group(n=47).The control group was given conventional drugs,and the study group was treated with a combination of conventional drugs and modified Qigui Wenbu Decoction.Clinical effects,TCM syndrome scores,blood pressure,urinary protein,serum sFlt1,Hcy and PLGF levels,oxidative stress indicators[malondialdehyde(MDA)and superoxide dismutase(SOD)]and pregnancy outcomes were compared between groups.Results:The total effective rate of treatment in the study group(93.62%)was higher than that in the control group(74.47%)(P<0.05).After treatment,TCM syndrome scores in the study group were lower than those in the control group(P<0.05).After treatment,SBP,DBP,urinary protein,serum sFlt1,Hcy and MDA levels in the study group were lower than those in the control group(P<0.05).Serum PLGF and SOD levels in the study group were higher than those in the control group(P<0.05).The cesarean section rate and postpartum hemorrhage rate in the study group(21.28%and 17.02%)were significantly lower than those in the control group(40.43%and 36.17%)(P<0.05).Conclusion:Modified Qigui Wenbu Decoction is effective in the treatment of ESPE,which can effectively improve the patients’blood pressure,urinary protein and serum sFlt1,Hcy and PLGF levels,alleviate oxidative stress reactions and improve pregnancy outcomes.
作者
巫家璐
王静
WU Jialu;WANG Jing(Department of Laboratory,Longquanyi District Traditional Chinese Medicine Hospital,Chengdu Sichuan610100,China;Department of Traditional Chinese Medicine,Jiangyou Second People’s Hospital,Jiangyou Sichuan 621700,China)
出处
《四川中医》
2024年第8期158-162,共5页
Journal of Sichuan of Traditional Chinese Medicine
