摘要
目的观察丹参注射液对重度妊娠期高血压疾病患者血管活性物质、肾功能影响及临床疗效。方法88例重度妊娠期高血压疾病患者随机分为治疗组和对照组。对照组采用常规西药治疗,治疗组在对照组基础上加用丹参注射液治疗,检测内皮素(ET-1)、一氧化氮(NO)和肾功能指标,评价临床疗效。结果①两组患者血浆ET-1浓度与治疗前比较均显著下降(P<0.05),且治疗组ET-1浓度显著低于对照组(P<0.05);NO浓度与治疗前比较显著上升(P<0.05),且治疗组NO浓度显著高于对照组(P<0.05);②两组患者血清尿素氮(BUN)、尿酸(UA)和肌肝(Gr)与治疗前比较均显著下降(P<0.05),且治疗组BUN、UA和Gr显著低于对照组(P<0.05)。结论丹参注射液能抑制重度妊娠期高血压疾病患者血管内皮细胞受损,改善肾功能,疗效显著,可作为治疗妊娠期高血压疾病的常规药物之一。
OBJECTIVE To observe the effects of vasoactive substances and renal function of patients with severe pregnancy induced hypertension（PIH） by treatment of danshen injection. METHODS 88 cases with PIH were divided randomly into the treatment group and control group. Conventional western medicine treatment was taken into control group, while danshen injection combined with conventional western medicine were taken into the treatment group. The endothelin （ET）, nitric oxide（NO）, renal function and clinical efficacy were observed. RESULTS （1）Compared with those per-treatment, the plasma ET-1 of two groups was significantly decreased （P〈0.05）, and the plasma ET-1 of treatment group was significantly lower than that of the control group （P〈0.05） ; Compared with those per-treatment, the plasma NO of two groups was significantly increased （P〈0.05）, and the plasma NO of treatment group was significantly higher than that of the control group （P〈0.05） ; （2）Compared with those per-treatment, the serum BUN, UA, Gr of two groups were significantly decreased （P〈0.05）, and the serum BUN, UA, Gr of 4reatment group were significantly lower than that of the control group （P〈0.05）. CONCLUSIONS Danshen injection can inhibit vascular endothelial cell damage from PIH patients and improve renal function, the clinical efficacy is significant. Danshen injection can be used to treat the PIH as conventional drug.
出处
《中国初级卫生保健》
2009年第7期87-88,共2页
Chinese Primary Health Care
关键词
重度妊高征
丹参注射液
内皮素
NO
肾功能
severe pregnancy-induced hypertension
danshen injection
endothelin
NO
renal function
