摘要
目的分析益胃解毒方治疗慢性萎缩性胃炎中的效果及对细胞周期蛋白E(Cyclin E)水平、辅助性T细胞(Th17)/调节性T细胞(Treg)比值的影响。方法选取2019年6月至2022年6月在河北省石家庄市中医院确诊的150例慢性萎缩性胃炎患者作为研究对象,按照随机数字表法分为益胃解毒方组、六君子汤组、益胃解毒方+六君子汤组,每组50例。益胃解毒方组使用益胃解毒方治疗,六君子汤组使用六君子汤治疗,益胃解毒方+六君子汤组使用益胃解毒方联合六君子汤治疗,均连续治疗24周。比较3组治疗效果、中医证候积分、Cyclin E水平、Th17/Treg比值、不良反应发生情况。结果益胃解毒方组治疗总有效率高于六君子汤组和益胃解毒方+六君子汤组,且益胃解毒方+六君子汤组高于六君子汤组,差异均有统计学意义(P<0.05)。治疗后3组各项中医证候积分低于治疗前,差异均有统计学意义(P<0.05)。治疗后益胃解毒方组各项中医证候积分低于六君子汤组和益胃解毒方+六君子汤组,且益胃解毒方+六君子汤组低于六君子汤组,差异均有统计学意义(P<0.05)。治疗后3组Cyclin E水平、Th17/Treg比值均低于治疗前,差异均有统计学意义(P<0.05)。治疗后益胃解毒方组Cyclin E水平、Th17/Treg比值低于六君子汤组和益胃解毒方+六君子汤组,且益胃解毒方+六君子汤组低于六君子汤组,差异均有统计学意义(P<0.05)。益胃解毒方组总不良反应发生率低于六君子汤组和益胃解毒方+六君子汤组,且益胃解毒方+六君子汤组低于六君子汤组,差异均有统计学意义(P<0.05)。结论益胃解毒方治疗慢性萎缩性胃炎效果显著,不仅能够改善患者临床症状,调节Cyclin E、Th17/Treg表达,还能减少不良反应发生,值得临床推广应用。
Objective To analyze the effect of Yiwei Jiedu decoction on chronic atrophic gastritis and its impact on Cyclin E level and helper T cells(Th17)to regulatory T cells(Treg)ratio.Methods A total of 150 patients with chronic atrophic gastritis diagnosed in Shijiazhuang Hospital of Traditional Chinese Medicine from June 2019 to June 2022 were selected as the research objects.According to the random number table method,they were divided into Yiwei Jiedu decoction group,Liujunzi decoction group and Yiwei Jiedu decoction+Liujunzi decoction group,with 50 cases in each group.The Yiwei Jiedu decoction group was treated with Yiwei Jiedu decoction,the Liujunzi decoction group was treated with Liujunzi decoction,and the Yiwei Jiedu decoction+Liujunzi decoction group was treated with Yiwei Jiedu decoction combined with Liujunzi decoction for 24 consecutive weeks.The treatment effect,Traditional Chinese Medicine Syndrome score,Cyclin E level,Th17/Treg ratio and the occurrence of adverse reactions were compared among the 3 groups.Results The total effective rate of Yiwei Jiedu decoction group was higher than that of Liujunzi decoction group and Yiwei Jiedu decoction+Liujunzi decoction group,and the total effective rate of Yiwei Jiedu decoction+Liujunzi decoction group was higher than that of Liujunzi decoction group,and the differences were statistically significant(P<0.05).After treatment,the scores of Traditional Chinese Medicine Syndrome scores in 3 groups were lower than before treatment,and the differences were statistically significant(P<0.05).After treatment,the Traditional Chinese Medicine Syndrome scores of Yiwei Jiefu decoction group were lower than those of Liujunzi decoction group and Yiwei Jiefu decoction+Liujunzi decoction group,and the Traditional Chinese Medicine Syndrome scores of Yiwei Jiefu decoction+Liujunzi decoction group were lower than those of Liujunzi decoction group,and the differences were statistically significant(P<0.05).After treatment,Cyclin E level and Th17/Treg ratio in 3 groups were lower than
作者
王立业
张艳彬
朱亚楠
常玉娟
李晶
柳康康
朱玉光
WANG Liye;ZHANG Ya′nbin;ZHU Ya′nan;CHANG Yujuan;LI Jing;LIU Kangkang;ZHU Yuguang(GUO Guangye Inheritance Studio,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei 050051,China)
出处
《检验医学与临床》
CAS
2024年第18期2728-2732,共5页
Laboratory Medicine and Clinic
基金
河北省中医药管理局科研计划项目(20203602102)。
