摘要
目的了解2020—2023年薛城区疑似预防接种异常反应(adverse event following immunization,AEFI)报告发生情况,为评价疫苗安全性,提高AEFI监测工作质量提供依据。方法通过国家免疫规划信息系统AEFI监测模块,按反应发生日期导出2020—2023年薛城区报告的AEFI个案;通过山东省预防接种信息系统,按接种地导出同期监测疫苗接种剂次,描述分析AEFI发生特征和报告发生率。结果2020—2023年薛城区AEFI总报告发生率13.17/10万剂,免疫规划疫苗、非免疫规划疫苗、附条件上市和紧急使用疫苗AEFI报告发生率分别为28.14/10万剂、20.72/10万剂、5.01/10万剂。接种同种疫苗第1剂发生AEFI占48.47%,接种1天后发生AEFI占59.82%。一般反应296例(90.80%)、异常反应17例(5.21%)、偶合症13例(3.99%),报告发生率分别为11.96/10万剂、0.69/10万剂、0.53/10万剂。严重和非严重AEFI报告发生率分别为0.57/10万剂、12.60/10万剂,95.40%的患者痊愈。男女性别比1.28∶1,2岁以下儿童占49.69%,散居儿童占60.12%,不同类型AEFI性别构成差异无统计学意义(χ^(2)=3.247,P>0.05),但年龄(χ^(2)=41.198)和职业构成(χ^(2)=50.028)差异均有统计学意义(P<0.05);6—8月AEFI报告数相对较多,分别占12.58%、14.11%、11.66%。不同年度各镇街报告发生率差异有统计学意义(χ^(2)=129.776,P<0.005)。结论2020—2023年薛城区所用疫苗安全性良好,但监测灵敏度需进一步提高。
Objective To analyze the occurrence of suspected adverse event following immunization(AEFI)in Xuecheng district from 2020 to 2023,in order to provide basis for evaluating the safety of vaccines and improving the quality of AEFI monitoring.Methods The information of the cases of AEFI in Xuecheng district from 20202023 were exported from the AEFI monitoring module of the National Immunization Planning Information System by the date of reaction occurrence,and the number of vaccine doses during the same period was derived from the Immunization Information System of Shandong Province.The characteristics of AEFI and reported incidence were descriptively analyzed.Results From 2020 to 2023,the total reported incidence rate of AEFI was 13.17/100000 doses in Xuecheng district.The reported incidence rates of AEFI of the immunization program vaccines,non-immunization program vaccines,conditionally marketed and emergency use vaccines was 28.14/100000,20.72/100000 and 5.01/100000 doses,respectively.The AEFI occurrence following first dose of same vaccine accounted for 48.47%,and the AEFI accounted for 59.82%after one day of the vaccination.There were 296 cases with general reactions accounted for 90.80%,17 cases with abnormal reactions accounted for 5.21%,and 13 cases with coincidental illness accounted for 3.99%.The reported incidence rate of general reaction,abnormal reaction and coincidental illness was 11.96/100000 doses,0.69/100000 doses and 0.53/100000 doses,respectively.The reported incidence rate of serious and non-serious AEFIs was 0.57/100000 doses,12.60/100000 doses,respectively,and 95.40%of cases with AEFI were cured.The ratio of the male to the female was 1.28:1.The children aged younger than 2 years old accounted for 49.69%.Scattered children accounted for 60.12%.There was no statistical difference in the proportions of gender with different AEFI(χ^(2)=3.247,P>0.05).There were statistical difference(P<0.05)in the proportion of age(χ^(2)=41.198)and occupation(χ^(2)=50.028).The reported number of AEFI was relati
作者
孙中环
王芳
种衍超
SUN Zhong-huan;WANG Fang;CHONG Yan-chao(The Center for Disease Control and Prevention of Xuecheng District,Zaozhuang,Shandong 277000,China)
出处
《疾病预防控制通报》
2024年第4期70-75,92,共7页
Bulletin of Disease Control & Prevention(China)
基金
枣庄市科技发展计划项目(2023NS33)。
关键词
疑似预防接种异常反应
发生率
疫苗
Suspected adverse events following immunization
Incidence rate
Vaccine
