摘要
目的:描述2015—2022年泰州市姜堰区疑似预防接种异常反应(AEFI)监测结果,评价疫苗安全性和监测敏感性。方法:对AEFI数据进行整理,采用描述性分析方法,对AEFI分布特征和相关指标进行流行病学分析;对于年报告发生率及各疫苗报告发生率的比较采用χ2检验。结果:2015—2022年泰州市姜堰区共计报告AEFI 981例,AEFI报告发生率为33.06/10万,其中一般反应888例,异常反应89例,偶合症4例。除新型冠状病毒疫苗外,主要集中在6、7月份,1、2月份最低;男女性别比为1.44∶1,<1岁367例,占比45.20%;88.05%的AEFI发生在接种1 d内。临床诊断以发热、红肿、硬结等一般反应症状诊断为主;免疫规划疫苗中,一般反应报告发生率较高的为百白破疫苗(无细胞)、白破疫苗,异常反应报告发生率较高的为麻风疫苗、麻腮风疫苗。结论:泰州市姜堰区AEFI监测敏感性尚可,疫苗安全性较好,但仍需进一步加强AEFI监测工作。
Objective:To describe the monitoring results of suspected adverse event following immunization(AEFI)in Jiangyan District,Taizhou City from 2015 to 2022,and to evaluate vaccine safety and monitoring sensitivity.Methods:The AEFI data were organized and the descriptive analysis method was used to analyze the distribution characteristics and related indicators of AEFI.The statistical method ofχ2 test was used to compare the annual reported incidence rates and reported incidence rates of various vaccines.Resulsts:From 2015 to 2022,a total of 981 cases of AEFI were reported in Jiangyan District,Taizhou City,with an incidence rate of 33.06/100000,including 888 cases of general reactions,89 cases of abnormal reactions,and 4 cases of coincidence.In addition to the COVID-19 vaccine,it was mainly concentrated in June and July,with the lowest level in January and February;The male-to-female ratio was 1.44∶1,and there were 367 cases under 1 year old,accounting for 45.20%,and 88.05%of AEFI occured within 1 day of vaccination.The clinical diagnosis was mainly based on general symptoms such as fever,redness,swelling,and induration.In immunization planning vaccines,the vaccines with higher incidence of general reactions were diphtheria,tetanus and acellular pertussis combined vaccine(DTaP),and diphtheria and tetanus combined vaccine(DT),while the vaccines with higher incidence of abnormal reactions were measles and rubella combined vaccine(MR)and measles mumps and rubella combined vaccine(MMR).Conclusion:The sensitivity of AEFI monitoring in Jiangyan District of Taizhou City is still acceptable,and the vaccine safety is good,but further efforts are needed to strengthen AEFI monitoring.
作者
刘宇
王志勇
唐万琴
LIU Yu;WANG Zhiyong;TANG Wanqin(Taizhou Jiangyan District Center for Disease Control and Prevention,Taizhou 225500 China;Taixing City Center for Disease Control and Prevention,Taixing 225400 China;Taizhou Center for Disease Control and Prevention,Taizhou 225300 China)
出处
《现代医学》
2024年第5期770-775,共6页
Modern Medical Journal
关键词
疑似预防接种异常反应
监测
疫苗
adverse event following immunization
surveillance
vaccine
