摘要
目的研究茵栀黄颗粒结合酪酸梭菌活菌散治疗新生儿病理性黄疸临床效果。方法研究纳入新生儿病理性黄疸总计142例(2021年2月—2023年2月收治),将患儿以随机数字表法分为观察组与对照组,各组71例,入组患儿均给予蓝光照射治疗,对照组患儿同时采取酪酸梭菌活菌散治疗,观察组患儿在对照组治疗基础上结合茵栀黄颗粒治疗,各组患儿数据观察:治疗效果、治疗前后血清胆红素水平变化及中医症候积分(面目皮肤发黄、不欲吮乳、唇干、小便深黄、大便白如陶土等)变化、黄疸消退时间及住院时间、免疫功能指标变化、不良反应。结果观察组患儿与对照组总有效率比较(97.18%vs88.73%),P<0.05;治疗前,各组患儿血清总胆红素(Total bilirubin,TBil)及间接胆红素(Indirect bilirubin,IBil)、结合胆红素(Bound bilirubin,DBil)等胆红素指标、中医症候积分(面目皮肤发黄、不欲吮乳、唇干、小便深黄、大便白如陶土等)、CD^(+)_(4)T淋巴细胞、CD^(+)_(8)T淋巴细胞、CD^(+)_(4)/CD^(+)_(8)等比较,P>0.05,治疗后各组患者TBil、IBil、DBil、中医症候积分(面目皮肤发黄、不欲吮乳、唇干、小便深黄、大便白如陶土等)等指标均下降,CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8)均上升,观察组患儿治疗后TBil、IBil、DBil、中医症候积分(面目皮肤发黄、不欲吮乳、唇干、小便深黄、大便白如陶土等)等指标低于对照组,CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8)等指标高于对照组,P<0.05;与对照组患儿黄疸消退时间及住院时间比较,观察组患儿各项时间均更短,P<0.05;两组患儿不良反应率均较低,P>0.05。结论茵栀黄颗粒结合酪酸梭菌活菌散治疗新生儿病理性黄疸临床效果显著,患儿症状改善,恢复快,患儿免疫功能改善,且治疗安全性高,值得应用。
Objective To study the clinical effect and safety of Yinzhihuang Granules(茵栀黄颗粒)combined with Clostridi-um Caseinate Live Powder in the treatment of neonatal pathological jaundice.Methods A total of 1_(4)2 cases of neonatal pathologi-cal jaundice(admitted from February 2021 to February 2023)were included in this study.The children were divided into obser-vation group and control group by random number table method,with 71 cases in each group.All the enrolled children were trea-ted with blue light irradiation,while the control group were treated with Live Clostridium Caseinate Powder.The observation group combined with Yinzhihuang Granules on the basis of the control group.The treatment effect,serum bilirubin level changes before and after treatment and traditional Chinese medicine syndrome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.)changes,jaundice regression time and hospital stay,immune function index changes and adverse reactions of two groups were compared.Results The total effective rates of observation group and control group were 97.1_(8)%vs 88.73%(P<0.05).Before treatment,the levels of total bilirubin(TBil),indirect bilirubin(IBil),bound bilirubin(DBil),total bilirubin(TBIL)and indirect bilirubin(IBIL)and other bilirubin indexes were detected in two groups.TCM syn-drome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.),CD^(+)_(4)T lymphocytes,CD^(+)_(8)T lymphocytes and CD^(+)_(4)/CD^(+)_(8)were not significant(P>0.05).After treatment,the levels of TBil,IBil and DBil,TCM syndrome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.)were all decreased in two groups,and the values of CD^(+)_(4)and CD^(+)_(4)/CD^(+)_(8)were all increased.After treatment,the levels of TBil,IBil and DBil,TCM syndrome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.)in the observa
作者
王向平
张泽佳
陈占芳
WANG Xiangping;ZHANG Zejia;CHEN Zhanfang(The First People's Hospital of Datong,Datong 037004,Shanxi,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第9期228-231,共4页
Chinese Archives of Traditional Chinese Medicine
基金
山西省卫生计生委员会科研项目(201602014)。
关键词
新生儿病理性黄疸
茵栀黄颗粒
酪酸梭菌活菌散
胆红素
中医症候积分
免疫功能
不良反应
neonatal pathological jaundice
Yinzhihuang Granules(茵栀黄颗粒)
Clostridium Caseinate Live Powder
biliru-bin
TCM symptom score
immune function
adverse reaction
