摘要
The continuous emergence of drug-resistant bacteria has become a serious threat to human and animal health.Developing new non-antibiotic therapeutic drugs with high efficiency and low resistance is a promising strategy for combating drug-resistant bacteria.Here,a novel composite structure based on a hollow metal-organic framework(MOF)wrapped Au nanorod and loaded Pt nanoparticles(Au NR@H-ZIF-8@Pt)is designed for combating drug-resistant bacteria.The Au NR@H-ZIF-8@Pt composite structures serve a twofold purpose:(1)showing superior photothermal conversion efficiency under near-infrared light irradiation,thus achieving an antibacterial effect based on photothermal effect,and(2)exhibiting high-efficiency peroxidase-like activity,and effectively killing bacteria by reactive oxygen species(ROS)generated in situ.By combining photothermal and catalytic effects for in vitro antibacterial experiments,Au NR@H-ZIF-8@Pt exhibits efficient,rapid,broad-spectrum antibacterial activity(99.7%for Pseudomonas aeruginosa and 98.3%for Staphylococcus aureus).In addition,in vivo experiments further demonstrate the advantages of the material in promoting bacterial infection wound healing.This study not only facilitates the design of novel biological nanomaterials,but also provides new ideas for combating drug-resistant bacteria.
耐药菌的不断出现已成为人类和动物健康的严重威胁.开发高效、低耐药的新型非抗生素治疗药物是对抗耐药菌的有效策略.在这里,我们设计了一种新型的复合结构,即中空金属有机框架(MOF)包裹金纳米棒并负载铂纳米颗粒(Au NR@H-ZIF-8@Pt)用以对抗耐药细菌.Au NR@H-ZIF-8@Pt复合结构具有双重作用:(1)在近红外光照射下表现出优异的光热转换效率,从而实现基于光热效应的抗菌作用;(2)表现出高效的过氧化物酶样活性,通过原位产生的活性氧(ROS)有效杀灭细菌.结合光热和催化作用进行体外抗菌实验,Au NR@H-ZIF-8@Pt表现出高效、快速、广谱的抗菌活性(对铜绿假单胞菌和金黄色葡萄球菌的灭菌效果分别高达99.7%和98.3%).此外,体内实验进一步证明了该材料在促进细菌感染创面愈合方面的优势.本研究不仅有利于新型生物纳米材料的设计,也为对抗耐药菌提供了新思路.
作者
Rong Li
Shasha Chen
Xingang Zhang
Fan Zeng
Xianyin Song
Jia Yin
Changzhong Jiang
李蓉;陈莎莎;张新刚;曾帆;宋先印;尹佳;蒋昌忠(Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education,Key Laboratory for Matter Microstructure and Function of Hunan Province,Department of Physics and Synergetic Innovation Center for Quantum Effects and Applications,Hunan Normal University,Changsha,410081,China;Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation,College of Life Sciences,Hunan Normal University,Changsha,410081,China;College of Materials Science and Engineering,Hunan University,Changsha,410082,China)
基金
supported by the Natural Science Foundation of Hunan Province(2021JJ40356)。
