摘要
目的探讨血清总氧化态(TOS)及总抗氧化态(TAS)在可手术切除的进展期胃癌患者中的表达及临床意义。方法选取140例进展期胃癌手术患者和140例健康体检者,分别作为观察组和健康组,使用分光光度计检测两组受试者血清TOS、TAS水平,并计算氧化应激指数(OSI)。比较观察组和健康组受试者TOS、TAS、OSI,以及手术前后观察组患者TOS、TAS、OSI。根据术后腹腔感染情况将进展期胃癌患者分为腹腔感染组(n=20)和无腹腔感染组(n=120),比较腹腔感染组和无腹腔感染组患者TOS、TAS、OSI。采用Pearson相关性分析法分析TOS、TAS与OSI的相关性。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析TOS、TAS单独及联合检测对进展期胃癌患者术后腹腔感染的预测效能。结果观察组患者TOS、OSI均明显高于健康组,TAS明显低于健康组,差异均有统计学意义(P﹤0.01)。术后,观察组患者TOS、OSI均高于术前,TAS低于术前,差异均有统计学意义(P﹤0.05)。腹腔感染组患者TOS、OSI均明显高于无腹腔感染组,TAS明显低于无腹腔感染组,差异均有统计学意义(P﹤0.01)。TOS与OSI呈正相关(r=0.391,P﹤0.01),TAS与OSI呈负相关(r=-0.388,P﹤0.01)。TOS、TAS联合检测预测进展期胃癌患者术后腹腔感染的AUC最大,灵敏度、阴性预测值均高于二者单独检测。结论进展期胃癌患者TOS、OSI较高,TAS较低,并且与术后腹腔感染情况密切相关。TOS、TAS联合检测对进展期胃癌患者术后腹腔感染的预测效能较高。
Objective To investigate the expression and clinical significance of serum total oxidation status(TOS)and total antioxidant status(TAS)in patients with surgically resectable advanced gastric cancer.Method A total of 140 patients with advanced gastric cancer who underwent surgery and 140 healthy subjects were selected as the observation group and healthy group,respectively.Serum TOS and TAS levels of the two groups were detected by spectrophotometer,and the oxidative stress index(OSI)was calculated.The TOS,TAS and OSI in observation group and healthy group were compared,and the TOS,TAS and OSI in observation group before and after operation were also compared.The advanced gastric cancer patients were divided into abdominal infection group(n=20)and non-abdominal infection group(n=120)according to postoperative abdominal infection,and the TOS,TAS and OSI were compared between the two groups.Pearson correlation analysis was used to analyze the correlation between TOS,TAS and OSI.Receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the predictive efficacy of TOS and TAS single and combined detection for postoperative abdominal infection in patients with advanced gastric cancer.Result The TOS and OSI in observation group were significantly higher than those in healthy group,the TAS was significantly lower than that in healthy group,and the differences were statistically significant(P<0.01).After operation,the TOS and OSI in observation group were higher than those before operation,the TAS was lower than that before operation,and the differences were statistically significant(P<0.05).The TOS and OSI in abdominal infection group were significantly higher than those in non-abdominal infection group,the TAS was significantly lower than that in non-abdominal infection group,and the differences were statistically significant(P<0.01).TOS was positively correlated with OSI(r=0.391,P<0.01).TAS was negatively correlated with OSI(r=-0.388,P<0.01).The AUC of TOS and TAS combined detection w
作者
杜学芳
张利利
马尚超
张彩凤
张超群
姬娟娟
DU Xuefang;ZHANG Lili;MA Shangchao;ZHANG Caifeng;ZHANG Chaoqun;JI Juanjuan(First Ward,Department of Gastroenterology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,He’nan,China;Department of Intensive Care Medicine,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,He’nan,China)
出处
《癌症进展》
2024年第14期1577-1580,共4页
Oncology Progress
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200506)。
关键词
总氧化态
总抗氧化态
氧化应激指数
进展期胃癌
腹腔感染
total oxidation status
total antioxidant status
oxidative stress index
advanced gastric cancer
abdominal infection
