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Enhancing cell adhesive and antibacterial activities of glass-fibre-reinforced polyetherketoneketone through Mg and Ag PIII

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摘要 Glass-fibre-reinforced polyetherketoneketone(PEKK-GF)shows great potential for application as a dental implant restoration material;however,its surface bioinertness and poor antibacterial properties limit its integration with peri-implant soft tissue,which is critical in the long-term success of implant restoration.Herein,functional magnesium(Mg)and silver(Ag)ions were introduced into PEKK-GF by plasma immersion ion implantation(PIII).Surface characterization confirmed that the surface morphology of PEKK-GF was not visibly affected by PIII treatment.Further tests revealed that PIII changed the wettability and electrochemical environment of the PEKK-GF surface and enabled the release of Mg^(2+)and Ag^(+)modulated by Giavanni effect.In vitro experiments showed that Mg/Ag PIII-treated PEKK-GF promoted the proliferation and adhesion of human gingival fibroblasts and upregulated the expression of adhesion-related genes and proteins.In addition,the treated samples inhibited the metabolic viability and adhesion of Streptococcus mutans and Porphyromonas gingivalis on their surfaces,distorting bacterial morphology.Mg/Ag PIII surface treatment improved the soft tissue integration and antibacterial activities of PEKK-GF,which will further support and broaden its adoption in dentistry.
出处 《Regenerative Biomaterials》 SCIE EI CSCD 2023年第1期1278-1293,共16页 再生生物材料(英文版)
基金 Qiang Wei(State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University)for guidance in using scanning electron microscope(No.2020C017)and 3D profilometer(No.2020ACA0).
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