摘要
Repairing osteoporotic bone defects is still a major clinical challenge.Recent studies have revealed that immune response is also essential in osteogenesis.The intrinsic inflammatory response of the host,especially the M1/M2 polarization status and inflammatory secretory function of macrophages,can directly affect osteogenic differentiation.Therefore,in this study,an electrospun naringin-loaded microspheres/sucrose acetate isobutyrate(Ng-m-SAIB)system was constructed to investigate its effect on the polarization of macrophage and osteoporotic bone defects.The results of both in vitro and in vivo experiments showed that Ng-m-SAIB had good biocompatibility and could promote the polarization of macrophage toward M2,thereby forming a favorable microenvironment for osteogenesis.The animal experiments also showed that Ng-m-SAIB could promote the osteogenesis of critical size defects in the skull of the osteoporotic model mouse(the senescence-accelerated mouse-strain P6).Together,these results collectively suggested that Ng-m-SAIB might be a promising biomaterial to treat osteoporotic bone defects with favorable osteo-immunomodulatory effects.
基金
support from the National Natural Science Foundation of China(No.81970914).
