摘要
骨愈合是一个复杂的、被精细调控的过程,涉及到炎性反应、血管新生、间充质干细胞分化、血管内皮细胞及骨相关细胞增殖、细胞自噬等生物学表型。从生物学表型的角度出发,结合患者的骨不连危险因素等个体化特点,能够以一种新的视角为骨不连治疗方式的合理选择提供参考。骨形态发生蛋白-2(BMP-2)、成纤维细胞生长因子-2(FGF-2)、runt相关转录因子2(RUNX2)及血管内皮生长因子(VEGF)等分子参与调控骨愈合的多种生物学表型,是骨不连治疗的重要靶点。掌握骨愈合的生物学表型及分子靶点,能够加深对骨不连治疗方案的机制认识,有助于基础研究向临床治疗的转化应用。为此,本文综述了骨不连常见治疗方式所对应的主要生物学表型,并分析了各表型中的重要分子机制。
Bone healing is a complex and orchestrated process,involving in inflammation,angiogenesis,mesenchymal stem cells differentiation,vascular endothelial cells and skeletal cells proliferation and cell autophagy.The individualized differences of patients including risk factors,combined with the perspective of phenotype can provide a novel view for the treatment of bone unhealing.Bone morphogenetic protein-2(BMP-2),fibroblast growth factor-2(FGF-2),runt-related transcription factor 2(RUNX2)and vascular endothelial growth factor(VEGF)take part in multiple phenotypes of bone healing,thus these candidates are the main treatment targets of bone unhealing.Taking advantage of these phenotypes and molecular mechanisms is beneficial for the understanding of mechanisms of fracture healing and helpful for the transformation from laboratory research to the clinical application.Here we characterized the main phenotypes and mechanisms in the treatment of bone unhealing.
作者
时迎旭
高明
王叶新
孟纯阳
王海滨
Shi Yingxu;Gao Ming;Wang Yexin;Meng Chunyang;Wang Haibin(Department of Orthopedics,Affiliated Hospital of Jining Medical University,Jining 272029,China)
出处
《中华实验外科杂志》
CAS
北大核心
2021年第11期2285-2290,共6页
Chinese Journal of Experimental Surgery
基金
济宁医学院高校教师扶持基金项目(JYFC2019FKJ214)
济宁医学院附属医院博士科研基金资助项目(2021-BS-009)。
关键词
生物学表型
分子机制
交互作用
转化医学
Biological phenotype
Molecular mechanism
Crosstalk
Translational medicine
