摘要
目的观察健骨复元汤治疗小儿尺桡骨闭合性骨折的疗效及对患儿炎症因子和骨代谢指标的影响。方法将82例尺桡骨闭合性骨折患儿按照随机数字表法分为2组,对照组41例予克氏针内固定治疗,治疗组41例在对照组治疗基础上联合健骨复元汤口服。2组均治疗6周。比较2组疗效;治疗前及疗程结束后3、6周比较2组骨代谢指标成纤维细胞生长因子(FGF-2)、转化生长因子β_(1)(TGF-β_(1))、骨形态发生蛋白-2(BMP-2)变化;比较2组治疗前后炎症因子白细胞介素(IL)-1、IL-6、肿瘤坏死因子α(TNF-α)及IL-2变化。观察2组不良反应发生情况。结果治疗组优良率97.56%(40/41),对照组优良率85.37%(35/41),治疗组疗效优于对照组(P<0.05)。2组疗程结束后3周FGF-2、TGF-β_(1)均较本组治疗前升高(P<0.05),且治疗组高于对照组(P<0.05);疗程结束后6周FGF-2、TGF-β_(1)均较本组治疗前降低(P<0.05),且治疗组低于对照组(P<0.05);2组疗程结束后3、6周BMP-2均高于本组治疗前(P<0.05),疗程结束后6周BMP-2高于治疗后3周(P<0.05);治疗组疗程结束后3、6周BMP-2均高于对照组同期(P<0.05)。2组治疗后IL-1、IL-2、IL-6及TNF-α水平均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。治疗组不良反应发生率2.44%(1/41),对照组不良反应发生率14.63%(6/41),治疗组不良反应发生率低于对照组(P<0.05)。结论健骨复元汤能通过减轻患儿骨折损伤引起的炎性反应,改善骨代谢,从而促进骨折愈合。
Objective To observe the curative effect of Jiangu Fuyuan Decoction on children with closed fracture(CF)of the radius and ulna and its influence on inflammatory factors(IF)and bone metabolism indexes(BMI).Methods Totally 82 children with CF of the radius and ulna were randomly divided into 2 groups,41 cases in treatment group were treated with Kirschner wire internal fixation combined with oral Jiangu Fuyuan Decoction,41 cases in control group with similarly treated except for oral Jiangu Fuyuan Decoction.Treated for 6 weeks,aiming to compare bone metabolism indexes including fibroblast growth factor(FGF-2),transforming growth factorβ_(1)(TGF-β_(1))and bone morphogenetic protein-2(BMP-2),inflammatory factors including interleukin-1(IL-1),IL-2,IL-6,and tumor necrosis factor-α(TNF-α)between groups before treatment and at the 3rd and 6th weeks post-treatment,the curative effect and incidence of adverse reactions was counted.Results The superior rate was better in treatment group than in control group[97.56%(40/41)vs 85.37%(35/41),(P<0.05),respectively].Compared with before treatment,FGF-2 and TGF-β_(1) in groups were significantly upregulated at the 3rd weeks post-treatment(P<0.05),which upregulated notably in treatment group when compared with cortrol group(P<0.05);FGF-2 and TGF-β_(1) in groups were significantly downregulated at the 6th week post-treatment(P<0.05),improvement of which in treatment group were significantly better(P<0.05);BMP-2 in groups were remarkably increased at the 3rd and 6th week post-treatment than before treatment(P<0.05),which was significantly increased in treatment group(P<0.05);BMP-2 in groups at the 6th weeks post-treatment was higher than that at the 3rd weeks(P<0.05);IL-1,IL-2,IL-6 and TNF-αin groups were remarkably decreased after treatment,which in treatment group significantly decreased(P<0.05).The incidence of adverse reactions was remarkably lower in treatment group than in control group[2.44%(1/41)vs 14.63%(6/41),(P<0.05),respectively].Conclusion For children with CF of
作者
李伟
吴声忠
黄华
吴闵
LI Wei;WU Shengzhong;HUANG Hua;WU Min(Department of Orthopedics,Guizhou Orthopedics Hospital,Guiyang,Guizhou 550002;不详)
出处
《河北中医》
2021年第7期1087-1091,共5页
Hebei Journal of Traditional Chinese Medicine
基金
贵州省中医药管理局中医药、民族医药科学技术研究课题(编号:QZYY-2018-056)。
关键词
尺骨骨折
尺神经
损伤
桡骨骨折
小儿
中药疗法
Ulnar fracture
Ulnar nerve,damage
Radius fracture
Children
Traditional Chinese medicine therapy
