摘要
目的研究血清标志物可溶性人髓系细胞触发受体⁃1(sTREM⁃1)和水通道蛋白5(AQP5)是对白内障术后感染性眼内炎的预测价值。方法选择2021年10月⁃2023年10月期间在成都爱尔眼科医院行手术治疗的白内障患者146例作为观察组,另取同期进行体检的健康者120名作为对照组,比较两组间血清sTREM⁃1、AQP5水平的差异;根据观察组术后是否发生白内障术后感染性眼内炎并分为感染亚组(n=31)和非感染亚组(n=115),比较两亚组间血清sTREM⁃1、AQP5水平及临床资料的差异,采用二元logistic回归分析白内障术后感染性眼内炎的影响因素,采用受试者工作特征(ROC)曲线分析血清sTREM⁃1、AQP5对白内障术后感染性眼内炎的预测价值。结果观察组患者的血清sTREM⁃1、AQP5水平高于对照组,差异有统计学意义(t=13.235、12.484,P<0.05);感染亚组患者的血清sTREM⁃1、AQP5水平以及糖尿病比例、手术时间、术中出血量、玻璃体溢出比例均高于非感染亚组,差异有统计学意义(t=6.536、4.026、4.392、6.934、10.544、14.508,P<0.05);有糖尿病史、手术时间延长及血清sTREM⁃1、AQP5水平增加是白内障术后感染性眼内炎的危险因素(P<0.05);血清sTREM⁃1、AQP5对白内障术后感染性眼内炎具有预测价值,预测的曲线下面积分别为0.807、0.905。结论血清sTREM⁃1、AQP5水平增加与白内障术后感染性眼内炎相关,两项指标均对白内障术后感染性眼内炎具有预测价值。
Objective To study the predictive value of serum markers soluble triggering receptor expressed on human myeloid cells⁃1(sTREM⁃1)and aquaporin 5(AQP5)for infectious endophthalmitis after cataract surgery.Methods 146 cataract patients who underwent surgical treatment at Chengdu Aier Ophthal⁃mology Hospital from October 2021 to October 2023 were selected as the observation group,and 120 healthy subjects who underwent physical examinations during the same period were selected as the control group.The differences of serum sTREM⁃1 and AQP5 levels between the two groups were compared.The observation group was further divided into an infected subgroup(n=31)and a non⁃infected subgroup(n=115)based on whether postoperative infectious endophthalmitis occurred after cataract surgery.The differences of serum sTREM⁃1 and AQP5 levels and clinical data between the two subgroups were compared,and the influencing factors of infec⁃tious endophthalmitis after cataract surgery were analyzed by binary logistic regression.The predictive value of serum sTREM⁃1 and AQP5 for infectious endophthalmitis after cataract surgery was analyzed by receiver operat⁃ing characteristic(ROC)curve analysis.Results The levels of serum sTREM⁃1 and AQP5 in the observation group were higher than those in the control group,the difference was statistically significant(t=13.235,12.484,P<0.05).The levels of serum sTREM⁃1 and AQP5,as well as the proportion of diabetes mellitus,op⁃eration time,intraoperative blood loss and proportion of vitreous spill in the infected subgroup were higher than those in the non⁃infected subgroup,with statistical significance(t=6.536,4.026,4.392,6.934,10.544,14.508,P<0.05).History of diabetes mellitus,prolonged operation time and increased levels of serum sTREM⁃1 and AQP5 were identified as risk factors for infectious endophthalmitis after cataract surgery(P<0.05).Serum sTREM⁃1 and AQP5 showed predictive value for infectious endophthalmitis after cataract surgery,and the pre⁃dicted areas under the cur
作者
潘雪菲
邵婷
刘青
PAN Xuefei;SHAO Ting;LIU Qing(Chengdu Aier Ophthalmology Hospital Ophthalmology Department,Sichuan,Chengdu,China,610041)
出处
《分子诊断与治疗杂志》
2024年第8期1484-1487,1492,共5页
Journal of Molecular Diagnostics and Therapy
基金
成都市卫生健康委员会科研项目(2021368)。
