摘要
目的分析血清糖类抗原125(CA125)、癌胚抗原(CEA)、糖类抗原199(CA199)检验在早期宫颈癌诊断中的应用效果。方法选取47例早期宫颈癌患者作为观察组,另选取同期收治的47例宫颈良性疾病患者作为对照组,对其资料进行回顾性分析。两组患者均接受血清CA125、CEA、CA199检验。对比两组患者血清CA125、CEA、CA199水平以及血清CA125、CEA、CA199单独检验与联合检验对于早期宫颈癌的诊断效能。结果观察组患者CA125为(40.55±7.65)U/ml,CEA为(8.20±1.85)ng/ml,CA199为(38.56±7.70)U/ml;对照组患者CA125为(20.56±5.89)U/ml,CEA为(3.02±1.50)ng/ml,CA199为(25.00±5.05)U/ml。与对照组相比,观察组血清CA125、CEA、CA199水平更高(P<0.05)。血清CA125、CEA、CA199联合检验早期宫颈癌的灵敏度95.74%、特异度93.62%、符合率94.68%均高于单独CA125检验的72.34%、70.21%、71.28%,单独CEA检验的76.60%、74.45%、75.53%,单独CA199检验的76.60%、65.96%、71.28%(P<0.05)。结论血清CA125、CEA与CA199在早期宫颈癌中的表达明显上升,联合检验能够提高诊断效能,为后续诊疗工作提供重要的参考依据。
Objective To analyze the application effect of serum carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)tests in the diagnosis of early cervical cancer.Methods 47 patients with early cervical cancer were selected as the observation group,and another 47 patients with benign cervical diseases during the same period were selected as the control group.Both groups of patients underwent serum CA125,CEA,and CA199 tests.The levels of serum CA125,CEA,and CA199 were compared between the two groups,as well as the diagnostic efficacy of individual and combined tests for serum CA125,CEA,and CA199 in early cervical cancer.Results In the observation group,CA125 was(40.55±7.65)U/ml,CEA was(8.20±1.85)ng/ml,and CA199 was(38.56±7.70)U/ml;in the control group,CA125 was(20.56±5.89)U/ml,CEA was(3.02±1.50)ng/ml,and CA199 was(25.00±5.05)U/ml.Compared with the control group,the levels of serum CA125,CEA and CA199 in the observation group were higher(P<0.05).The sensitivity,specificity and conformity rate of the combined test of serum CA125,CEA,and CA199 for early cervical cancer were 95.74%,93.62%and 94.68%,all higher than 72.34%,70.21%and 71.28%of CA125 test,76.60%,74.45%and 75.53%of CEA test,and 76.60%,65.96%and 71.28%of CA199 test(P<0.05).Conclusion The expression of serum CA125,CEA,and CA199 is significantly increased in early cervical cancer.Combined testing can improve diagnostic efficacy and provide important reference for subsequent diagnosis and treatment work.
作者
梁才
LIANG Cai(Laboratory Department,Weihai Maternal and Child Health Hospital,Weihai 264200,China)
出处
《中国现代药物应用》
2024年第16期75-78,共4页
Chinese Journal of Modern Drug Application
关键词
糖类抗原125
癌胚抗原
糖类抗原199
早期宫颈癌
Carbohydrate antigen 125
Carcinoembryonic antigen
Carbohydrate antigen 199
Early cervical cancer
