摘要
目的:探讨妊娠相关蛋白A(PAPP-A)、胎盘生长因子(PLGF)与同型半胱氨酸(Hcy)联合检测在孕早期先兆流产的预测价值。方法:选择2022年1月—2023年9月在上饶市立医院住院的孕早期先兆流产患者90例并设为病例组,90例健康孕妇并设为参考组。测定PAPP-A、PLGF、Hcy水平。对比两组PLGF、PAPP-A与Hcy检测值差异,并绘制受试者操作特征(ROC)曲线,分析PLGF、PAPP-A、Hcy单一与联合检测预测孕早期先兆流产的价值。结果:病例组PLGF、PAPP-A均低于参考组,Hcy较参考组高,差异均有统计学意义(P<0.05);PLGF、PAPP-A、Hcy联合检测预测孕早期先兆流产的曲线下面积(AUC)为0.900[95%CI(0.533,0.967],敏感度为0.933,特异度为0.800,约登指数为0.733,均高于单一检测。结论:孕早期先兆流产患者PLGF、PAPP-A、Hcy水平表达异常,三者联合检测可提高预测准确性,为临床治疗提供参考。
Objective:To investigate the predictive value of pregnancy-associated plasma protein A(PAPP-A),placental growth factor(PLGF)and homocysteine(Hcy)combined detection in the first trimester of threatened abortion.Method:From January 2022 to September 2023,90 patients with threatened abortion in first trimester pregnancy who were hospitalized in Shangrao Municipal Hospital were selected as case group and 90 healthy pregnant women were selected as reference group.PAPP-A,PLGF and Hcy levels were determined.The differences of PLGF,PAPP-A and Hcy detection values between the two groups were compared,and receiver operating characteristic(ROC)curve was drawn to analyze the value of single PLGF,PAPP-A and HCY and combined detection in predicting threatened abortion in the first trimester.Result:The PLGF and PAPP-A of the case group were lower than those of the reference group,and the Hcy was higher than that of the reference group,the differences were statistically significant(P<0.05).The area under the curve(AUC)of PLGF,PAPP-A and Hcy combined detection for predicting threatened abortion in early pregnancy was 0.900[95%CI(0.533,0.967)],sensitivity was 0.933,specificity was 0.800,and Yodon index was 0.733,all of which were higher than those of single detection.Conclusion:The expression of PLGF,PAPP-A and Hcy are abnormal in patients with threatened abortion in first trimester pregnancy.The combined detection of the three can improve the prediction accuracy and provide reference for clinical treatment.
作者
苏小梅
郑楚豪
付安
SU Xiaomei;ZHENG Chuhao;FU An(Clinical Laboratory,Shangrao Municipal Hospital,Shangrao 334000,China)
出处
《中国医学创新》
CAS
2024年第24期121-124,共4页
Medical Innovation of China
基金
上饶市科技计划一般项目(2023CZDX40)。
关键词
先兆流产
胎盘生长因子
妊娠相关蛋白A
同型半胱氨酸
Threatened abortion
Placental growth factor
Pregnancy-associated plasma protein A
Homocysteine
