摘要
目的分析宁血方治疗脾虚湿热证急性上消化道出血(AUGB)的临床效果,通过网络药理学探讨其作用机制。方法收集2019年1月至2023年1月厦门市中医院脾胃科收治的70例符合AUGB(脾虚湿热证)入组标准的患者,按照治疗方案分为宁血方+常规治疗组(观察组)和常规治疗组(对照组)。比较两组治疗效果。并利用TCMSP筛选宁血方的活性成分及作用靶点,应用OMIM等数据库获得急性上消化道出血相关靶点,构建中药-有效成分-作用靶点网络图,以Metascape数据库进行GO分析和KEGG分析。结果临床研究纳入观察组、对照组各35例,治疗前基线水平无明显差异(P>0.05)。治疗后,观察组临床疗效94.29%优于对照组的85.71%(P<0.05);两组的中医症候积分均较治疗前降低,观察组积分低于对照组(P<0.05)。两组不良反应情况对比差异无统计学意义(P>0.05)。网络药理学筛选交集靶点143个,核心靶点38个。结论宁血方可有效促进脾虚湿热证上消化道出血患者止血,通过多成分-多靶点-多通路来治疗急性上消化道出血。
Objective To analyze the clinical effect of Ningxue formula in the treatment of acute upper gastrointestinal bleeding due to spleen deficiency and damp-heat syndrome,and to explore its mechanism of action through network pharmacology.Methods A total of 70 patients with AUGB(spleen deficiency and dampness-heat syndrome)admitted to the Spleen and Stomach Department of Xiamen Hospital of Traditional Chinese Medicine from January 2019 to January 2023 were collected and divided into Ningxue formula+conventional treatment group(observation group)and conventional treatment group(control group)according to the treatment plan.The therapeutic effect of the two groups was compared.In addition,TCMSP was used to screen the active ingredients and target of Ningxue formula,and OMIM and other databases were used to obtain the related targets of acute upper gastrointestinal bleeding.The network diagram of TCM-active ingredients-target was constructed,and the GO analysis and KEGG analysis were conducted using Metascape database.Results The clinical study included 35 cases in the observation group and the control group,and there was no significant difference in baseline levels before treatment(P>0.05).After treatment,the clinical efficacy of the observation group was 94.29%better than that of the control group,which was 85.71%(P<0.05);the TCM symptom scores of both groups were lower than before treatment,and the scores of the observation group were lower than those of the control group(P<0.05).There was no statistically significant difference in the comparison of adverse reactions between the two groups(P>0.05).Network pharmacology screened 143 intersection targets and 38 core targets.Conclusions Ningxue formula can effectively promote hemostasis in patients with upper gastrointestinal bleeding with spleen deficiency and damp-heat syndrome,and treat acute upper gastrointestinal bleeding through multi-component-multi-target-multi-pathway.
作者
林兰梅
吴耀南
陈一斌
陈丽凤
陈默
范丽玉
曹健
LIN Lanmei;WU Yaonan;CHEN Yibin;CHEN Lifeng;CHEN Mo;FAN Liyu;CAO Jian(Department of Spleen and Stomach,Xiamen Hospital of Traditional Chinese Medicine,Xiamen 361000,China;Department of TCM Diagnosis and Treatment,Xiamen Hospital of Traditional Chinese Medicine,Xiamen 361000,China)
出处
《中国医药指南》
2024年第25期1-5,共5页
Guide of China Medicine
基金
吴耀南全国名老中医药专家传承工作室专项资金(国中医药人教函〔2022〕75号)
福建中医药大学校管课题临床专项(XB2021110)。
关键词
宁血方
急性上消化道出血
网络药理学
临床研究
Ningxue formula
Acute upper gastrointestinal bleeding
Network pharmacology
Clinical research
