摘要
Objective To explore the correlations of transcranial sonography of substantia nigra(SN-TCS)characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease(PD).Methods Data of SN-TCS and craniocerebral MRI in 120 PD patients were retrospectively analyzed.The patients were divided into iron deposition positive group(positive group,n=46)and iron deposition negative group(negative group,n=74)according to quantitative susceptibility mapping(QSM)value.Then parameters of SN-TCS and MRI were compared between groups(both P<0.05),and correlation analysis were also performed.Results The proportion of high echo positive,strong echo area and QSM value of substantia nigra,as well as of hyper-substantia nigra area/midbrain area(S/M)in positive group were all higher than those in negative group(all P<0.001).No significant difference of midbrain area was found between groups(P>0.05).Strong echo area of substantia nigra and S/M based on SN-TCS were both low-medium positively correlated with substantia nigra QSM value showed on MRI(r=0.497,0.529,both P<0.001).Conclusion SN-TCS characteristics of PD patients were correlated with MRI iron deposition on substantia nigra,among which strong echo area and S/M were valuable for evaluating iron deposition on substantia nigra.
目的观察帕金森病(PD)经颅黑质超声(SN-TCS)特征与MRI黑质铁沉积的相关性。方法回顾性分析120例PD患者SN-TCS及颅脑MRI,根据黑质定量磁化率成像(QSM)测值将患者归入铁沉积阳性组(n=46,阳性组)及铁沉积阴性组(n=74,阴性组);比较2组SN-TCS及MRI参数并行相关性分析。结果阳性组黑质超声高回声阳性占比、强回声面积、QSM值,以及黑质强回声面积与中脑面积比值(S/M)均高于阴性组(P均<0.001);组间中脑面积差异无统计学意义(P>0.05)。SN-TCS所见黑质强回声面积及S/M均与MRI黑质QSM值呈低-中度正相关(r=0.497、0.529,P均<0.001)。结论PD患者SN-TCS特征与MRI黑质铁沉积存在相关性;其中,黑质强回声面积及S/M对评估黑质铁沉积具有一定价值。
出处
《中国医学影像技术》
CSCD
北大核心
2024年第8期1160-1163,共4页
Chinese Journal of Medical Imaging Technology
