摘要
目的:观察滋肾宁心安神汤配合重复经颅磁刺激治疗脑卒中后失眠心肾不交证的临床疗效。方法:选取90例脑卒中后失眠心肾不交证患者,按随机数字表法分为对照组和试验组各45例。对照组剔除4例,纳入41例,予以重复经颅磁刺激治疗。试验组剔除3例,纳入42例,予以滋肾宁心安神汤配合重复经颅磁刺激治疗。2组均治疗4周。比较2组临床疗效、匹兹堡睡眠质量指数(PSQI)评分、中医证候积分、睡眠柏林问卷(BQ)评分、血清褪黑素水平。结果:治疗4周后,试验组总有效率95.24%,高于对照组78.05%(P<0.05)。2组PSQI评分、中医证候积分、BQ评分均较治疗前降低(P<0.05),试验组PSQI评分、中医证候积分、BQ评分均低于对照组(P<0.05)。2组血清褪黑素水平均较治疗前升高(P<0.05),试验组血清褪黑素水平高于对照组(P<0.05)。结论:滋肾宁心安神汤配合重复经颅磁刺激治疗脑卒中后失眠心肾不交证可增强疗效,改善睡眠质量及睡眠呼吸紊乱,缓解临床症状,调节褪黑素水平。
Objective:To observe the clinical effect of Zishen Ningxin Anshen Decoction combined with repetitive transcranial magnetic stimulation on insomnia with non-interaction between the heart and the kidney syndrome after cerebral stroke.Methods:A total of 90 cases of patients with insomnia with non-interaction between the heart and the kidney syndrome after cerebral stroke were selected and divided into the control group and the trial group according to the random number table method,with 45 cases in each group.In the control group,four cases were excluded and 41 cases were included,and repetitive transcranial magnetic stimulation was given.In the trial group,three cases were excluded and 42 cases were included,and patients were treated with Zishen Ningxin Anshen Decoction combined with repetitive transcranial magnetic stimulation.Both groups were treated for four weeks.The clinical effects,Pittsburgh Sleep Quality Index(PSQI)scores,traditional Chinese medicine(TCM)syndrome scores,Berlin Questionnaire(BQ)scores and serum melatonin levels were compared between the two groups.Results:After four weeks of treatment,the total effective rate was 95.24%in the trial group,higher than that of 78.05%in the control group(P<0.05).The PSQI scores,TCM syndrome scores and BQ scores in the two groups were decreased when compared with those before treatment,and PSQI score,TCM syndrome score and BQ score in the trial group were lower than those in the control group(P<0.05).The serum melatonin levels in the two groups were increased when compared with those before treatment(P<0.05),and the serum melatonin level in the trial group was higher than that in the control group(P<0.05).Conclusion:Zishen Ningxin Anshen Decoction combined with repetitive transcranial magnetic stimulation for insomnia with non-interaction between the heart and the kidney syndrome after cerebral stroke can enhance the therapeutic effect,improve sleep quality and sleep-related breathing disorders,relieve clinical symptoms,and regulate melatonin levels.
作者
罗静
朱莎莎
陈林考
LUO Jing;ZHU Shasha;CHEN Linkao(Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China;Taizhou Central Hospital/Taizhou University Hospital,Taizhou Zhejiang 318000,China)
出处
《新中医》
CAS
2024年第16期42-46,共5页
New Chinese Medicine
关键词
脑卒中
失眠
心肾不交证
滋肾宁心安神汤
重复经颅磁刺激
褪黑素
Cerebral stroke
Insomnia
Non-interaction between the heart and the kidney syndrome
Zishen Ningxin Anshen Decoction
Repetitive transcranial magnetic stimulation
Melatonin
