摘要
目的探讨老年衰弱综合征患者血清同型半胱氨酸(Hcy)水平与认知功能的相关性。方法回顾性选取2022年9月至2023年6月在宁波市精神病院住院治疗的60例老年衰弱综合征患者,根据是否存在认知功能损伤分为认知正常组(24例)和认知障碍组(36例),比较两组认知功能评估成套测验(MCCB)各项评分及血清Hcy水平,采用Pearson检验分析血清Hcy水平与认知功能的相关性。结果认知障碍组MCCB各项评分均低于认知正常组,差异有统计学意义(P<0.05)。认知障碍组血清Hcy、肿瘤坏死因子-α(TNF-α)及白细胞介素(IL)-6水平均高于认知正常组[(17.89±0.90)μmol/L比(16.99±0.75)μmol/L、(33.39±4.01)ng/L比(27.19±4.81)ng/L、(23.67±4.36)ng/L比(20.27±4.23)ng/L],差异有统计学意义(P<0.05)。Pearson检验结果表明,血清Hcy水平与MCCB中连线、符号编码、词语记忆和学习、工作记忆/空间广度、推理和问题解决、视觉记忆和学习、社会认知及注意/警觉性评分呈负相关(r=-0.292、-0.443、-0.475、-0.418、-0.370、-0.391、-0.324、-0.367,P<0.05);血清Hcy水平与TNF-α、IL-6水平呈正相关(r=0.336、0.326,P<0.05)。结论血清Hcy水平与老年衰弱综合征患者认知功能损害有一定的相关性,血清Hcy水平增高时,患者认知损害症状越严重。
Objective:To explore the correlation between blood homocysteine(Hcy)level and cognitive function in elderly patients with frailty syndrome.Methods:Sixty elderly patients with frail syndrome who were hospitalized in Ningbo Mental Hospital from September 2022 to June 2023 were selected retrospectively,they were divided into the cognitive normal group(24 cases)and the cognitive impairment group(36 cases)based on the presence of cognitive impairment.The Matrics Consensus Cognitive Battery(MCCB)score and serum Hcy levels of the two groups were compared,and the correlation between Hcy level and cognitive function were analyzed by Pearson test.Results:The MCCB scores in the cognitive impairment group were lower than those in the cognitive normal group,there were statistical differences(P<0.05).The levels of serum Hcy,tumor necrosis factor-α(TNF-α)and interleukin(IL)-6 in the cognitive impairment group were higher than those in the cognitive normal group:(17.89±0.90)μmol/L vs.(16.99±0.75)μmol/L,(33.39±4.01)ng/L vs.(27.19±4.81)ng/L,(23.67±4.36)ng/L vs.(20.27±4.23)ng/L,there were statistical differences(P<0.05).Pearson test results showed that serum Hcy level were negatively correlated with alignment,symbol coding,word memory and learning,working memory/spatial span,reasoning and problem solving,visual memory and learning,social cognition and attention/alertness scores of MCCB(r=-0.292,-0.443,-0.475,-0.418,-0.370,-0.391,-0.324,-0.367,P<0.05).Serum Hcy level was positively correlated with TNF-αand IL-6 levels(r=0.336,0.326,P<0.05).Conclusions:There is a certain correlation between serum Hcy level and cognitive impairment in elderly patients with frail syndrome.When blood Hcy level increase,the symptoms of cognitive impairment in patients become more severe.
作者
孔娴波
应洁琼
金丹露
郑柯珍
王珊珊
Kong Xianbo;Ying Jieqiong;Jin Danlu;Zheng Kezhen;Wang Shanshan(Department of Health Care Medicine,Ningbo Mental Hospital,Ningbo 315040,China;Department of Rehabilitation,Ningbo Minkang Hospital,Ningbo 315040,China)
出处
《中国医师进修杂志》
2024年第8期685-688,共4页
Chinese Journal of Postgraduates of Medicine
基金
宁波市科技计划项目(2022J201)。
