摘要
目的:观察百令胶囊联合甲泼尼龙治疗过敏性紫癜(HSP)肾损伤患儿的效果。方法:选取2020年7月至2023年6月该院收治的166例HSP肾损伤患儿进行前瞻性研究,按随机数字表法将其分为对照组和研究组各83例。对照组采用甲泼尼龙治疗,研究组在对照组基础上联合百令胶囊治疗。比较两组临床疗效,治疗前后肾功能指标[血尿素氮(BUN)、单核细胞趋化因子(MCP-1)、胱抑素C(CysC)]水平、免疫指标[免疫球蛋白(Ig)G、IgA、IgM]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.77%(77/83),高于对照组的81.93%(68/83),差异有统计学意义(P<0.05);治疗后,两组BUN、MCP-1、CysC水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组IgG、IgA、IgM水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:百令胶囊联合甲泼尼龙治疗HSP肾损伤患儿可提高临床疗效,降低肾功能指标和免疫球蛋白指标水平,其效果优于单纯甲泼尼龙治疗。
Objective:To observe effects of Bailing capsules combined with Methylprednisolone in treatment of children with Henoch-Schönlein purpura(HSP)renal injury.Methods:A prospective study was conducted on 166 children with HSP renal injury admitted to this hospital from July 2020 to June 2023.According to the random number table method,they were divided into control group and study group,83 cases in each group.The control group was treated with Methylprednisolone,while the study group was treated with Bailing capsules on the basis of that of the control group.The clinical efficacy,the renal function indexes[blood urea nitrogen(BUN),monocyte chemotactic factor(MCP-1),serum cystatin C(CysC)]levels,the immune indexes[immunoglobulin(Ig)G,IgA,IgM]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.77%(77/83),which was higher than 81.93%(68/83)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of BUN,MCP-1 and CysC in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IgG,IgA and IgM in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bailing capsules combined with Methylprednisolone in the treatment of the children with HSP renal injury can improve the clinical efficacy and reduce the levels of renal function indexes and immunoglobulin indexes.Moreover,it is superior to simple Methylprednisolone treatment.
作者
张浩
牛宛柯
赵蕊
ZHANG Hao;NIU Wanke;ZHAO Rui(Department of Pediatrics of Nanyang Zhangzhongjing Hospital,Nanyang 473000 Henan,China)
出处
《中国民康医学》
2024年第16期113-115,共3页
Medical Journal of Chinese People’s Health
关键词
过敏性紫癜
肾损伤
百令胶囊
甲泼尼龙
肾功能
免疫功能
Henoch-Schönlein purpura
Kidney injury
Bailing capsules
Methylprednisolone
Renal function
Immune function
