摘要
目的探讨百令胶囊联合吗替麦考酚酯片治疗小儿过敏性紫癜性肾炎的临床疗效。方法选取2017年2月—2018年1月襄阳市中心医院收治的过敏性紫癜性肾炎患儿76例为研究对象,按照随机数字表法分为对照组和治疗组,每组各38例。对照组口服吗替麦考酚酯片,0.5g/次,2次/d。治疗组在对照组治疗的基础上口服百令胶囊,2粒/次,3次/d。两组患儿均连续治疗3个月。观察两组的临床疗效,比较两组的尿蛋白定量、尿红细胞、肾小球滤过率(eGFR)、尿微量白蛋白(m Alb)、T淋巴细胞亚群和细胞因子水平。结果治疗后,对照组和治疗组的总有效率分别为73.68%、92.11%,两组比较差异有统计学意义(P<0.05)。治疗后,两组尿蛋白定量、尿红细胞明显降低,mAlb水平明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组尿常规指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组CD3^+、CD4^+、CD4^+/CD8^+、自然杀伤(NK)细胞明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组T淋巴细胞亚群指标明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组白细胞介素-4(IL-4)水平明显降低,γ-干扰素(IFN-γ)、IL-4/IFN-γ明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组细胞因子水平明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论百令胶囊联合吗替麦考酚酯片治疗小儿过敏性紫癜性肾炎的临床疗效较好,可改善肾功能,增强免疫功能,降低细胞因子水平,具有一定的临床推广应用价值。
Objective To investigate the efficacy of Bailing Capsules combined with Mycophenolate Mofetil Tablets in treatment of allergic purpuric nephritis in children. Methods Children（76 cases） with allergic purpuric nephritis in Xiangyang Central Hospital from February 2017 to January 2018 were randomly divided into control and treatment groups, and each group had 38 cases. Patients in the control group were po administered with Mycophenolate Mofetil Tablets, 0.5 g/time, twice daily. Patients in the treatment group were po administered with Bailing Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and urinary protein quantitation, urine red blood cell count, eGFR, mAlb, T lymphocyte subsets, and cytokine levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.68% and 92.11%, and there was difference between two groups（P〈0.05）. After treatment, urinary protein quantitation and urine red blood cell count in two groups were significantly decreased, but the levels of mAlb in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And urine routine indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, CD3~＋, CD4~＋, CD4~＋/CD8~＋, and NK in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And T lymphocyte subsets indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, IL-4 levels in two groups were significantly increased, but IFN-γ and IL-4/IFN-γlevels in two groups were significantly decreased, and the difference was statistically significa
作者
钱丹
姜勇超
何茹
QIAN Dan;JIANG Yong-chao;HE Ru(Department of Pediatrics,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Sciences,Xiangyang 441021,China)
出处
《现代药物与临床》
CAS
2018年第11期2892-2896,共5页
Drugs & Clinic
