摘要
目的探讨花藤子颗粒联合氯雷他定片治疗荨麻疹的效果。方法本研究采用前瞻性随机对照分析,选取2022年3月至2023年6月收治的92例荨麻疹患者为研究对象,根据随机数字表法分为2组,每组46例。对照组患者予以氯雷他定片治疗,观察组在此基础上联合花藤子颗粒治疗,2组均连续治疗2周。观察2组临床疗效、症状积分、免疫功能指标[血清免疫球蛋白E(IgE)、补体C3、补体C4、嗜酸粒细胞计数(EOS)、C-反应蛋白(CRP)]、不良反应发生情况以及短期复发率。结果治疗2周后,观察组临床总有效率明显高于对照组,差异均有统计学意义(P<0.05);观察组瘙痒、风团数量、红晕程度各积分明显低于对照组,2组血清IgE、EOS、CRP水平降低,补体C3、补体C4水平升高,且观察组血清IgE、EOS、CRP水平低于对照组,补体C3、补体C4高于对照组(P<0.05);2组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05);随访6周,观察组短期复发率明显低于对照组(χ^(2)=4.870,P=0.027)。结论相较于氯雷他定片单药,联合花藤子颗粒治疗荨麻疹效果更佳,明显改善患者临床症状,调节机体免疫,降低短期复发率,且安全性较高。
Objective To explore the efficacy of Huatengzi granules combined with loratadine tablets in the treatment of urticaria.Methods This study was a prospective randomized controlled analysis involving 92 patients with urticaria admitted to the hospital from March 2022 to June 2023 as the study subjects.They were randomly assigned in a 1∶1 ratio to loratadine tablets(control group)or Huatengzi granules+loratadine tablets(observation group)for 2 weeks.The clinical efficacy,symptom scores,immune function indicators(serum immunoglobulin E[IgE],complement component 3[C3],C4,eosinophil count[EOS],C-reactive protein[CRP]),incidence of adverse reactions,and short-term recurrence rate were assessed.Results After 2 weeks of treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05).The scores of itching,number of urticaria wheals,and degree of redness in the observation group were significantly lower than those in the control group.Significantly decreased IgE,EOS,and CRP,and increased C3 and C4 in both groups were detected than those before treatment,with significant differences between groups(P<0.05).There was no statistical significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).After a 6-week follow-up,the short-term recurrence rate in the observation group was significantly lower than that in the control group(χ^(2)=4.870,P=0.027).Conclusion Compared to loratadine tablets alone,the combination of Huatengzi granules has a better therapeutic effect on urticaria,which can effectively improve clinical symptoms,it has certain immune regulatory effects and can reduce short-term recurrence rate,and with higher safety.
作者
原丽琼
蔡永莲
苏战豹
赵志明
YUAN Liqiong;CAI Yonglian;SU Zhanbao(Suzhou Hospital of TCM,Jiangsu,Suzhou 215007,China)
出处
《河北医药》
CAS
2024年第16期2481-2483,2487,共4页
Hebei Medical Journal
关键词
荨麻疹
花藤子颗粒
氯雷他定片
urticaria
Huatengzi granules
loratadine tablets
