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TMAO在消化系统恶性肿瘤中的研究进展

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摘要 消化系统恶性肿瘤发病率高、侵袭性强并且预后差,对人类生存构成严重威胁。氧化三甲胺(trimethylamine-N-oxide, TMAO)是肠道微生物代谢的重要成分,不仅与心房颤动、冠状动脉粥样硬化、心力衰竭、慢性肾脏病和糖尿病等疾病息息相关,还参与参与消化道系统恶性肿瘤的发生发展、侵袭和转移等过程。TMAO有望成为消化系统肿瘤早期诊断、靶向治疗及评估预后的标志物,本文就TMAO异常表达的致癌机制及其在消化系统恶性肿瘤中的研究做一综述。
出处 《临床荟萃》 CAS 2024年第7期664-667,共4页 Clinical Focus
基金 青海大学附属医院中青年科研基金一般项目——CAPS患者血TMAO水平变化及其预后的相关性研究(ASRF-2023-YB-08)。
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